Polymorphisms of the PPAR-γ (rs1801282) and Its Coactivator (rs8192673) Have a Minor Effect on Markers of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus
Joint Authors
Petrovič, Daniel
Starčević, Jovana Nikolajević
Šantl Letonja, Marija
Cokan Vujkovac, Andreja
Pleskovič, Aleš
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The present study was designed to clarify whether common single nucleotide polymorphisms (SNPs) of the Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) gene (rs1801282) and the Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 (PGC-1α) gene (rs8192673) are associated with markers of carotid and coronary atherosclerosis in Caucasians with type 2 diabetes mellitus (T2DM).
Patients and Methods.
595 T2DM subjects and 200 control subjects were enrolled in the cross-sectional study.
Markers of carotid atherosclerosis were assessed ultrasonographically.
In 215 out of 595 subjects with T2DM, a coronary computed tomography angiography (CCTA) was performed for diagnostic purposes.
Genotyping of either rs1801282 or rs8192673 was performed using KASPar assays.
Results.
In our study, we demonstrated an effect of the rs1801282 on markers of carotid atherosclerosis (presence of plaques) in Caucasians with T2DM in univariate and in multivariable linear regression analyses.
Finally, we did not demonstrate any association between either rs1801282 or rs8192673 and markers of coronary atherosclerosis.
Conclusions.
In our study, we demonstrated a minor effect of the rs1801282 on markers of carotid atherosclerosis (presence of plaques) in Caucasians with T2DM.
Moreover, we demonstrated a minor effect of the rs8192673 on CIMT progression in the 3.8-year follow-up in Caucasians with T2DM.
American Psychological Association (APA)
Pleskovič, Aleš& Šantl Letonja, Marija& Cokan Vujkovac, Andreja& Starčević, Jovana Nikolajević& Petrovič, Daniel. 2016. Polymorphisms of the PPAR-γ (rs1801282) and Its Coactivator (rs8192673) Have a Minor Effect on Markers of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus. PPAR Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115324
Modern Language Association (MLA)
Pleskovič, Aleš…[et al.]. Polymorphisms of the PPAR-γ (rs1801282) and Its Coactivator (rs8192673) Have a Minor Effect on Markers of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus. PPAR Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1115324
American Medical Association (AMA)
Pleskovič, Aleš& Šantl Letonja, Marija& Cokan Vujkovac, Andreja& Starčević, Jovana Nikolajević& Petrovič, Daniel. Polymorphisms of the PPAR-γ (rs1801282) and Its Coactivator (rs8192673) Have a Minor Effect on Markers of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus. PPAR Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115324
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115324