PPARs and Mitochondrial Metabolism: From NAFLD to HCC
Joint Authors
Galli, Andrea
Mello, Tommaso
Materozzi, Maria
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-27
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Metabolic related diseases, such as type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease (NAFLD), are widespread threats which bring about a significant burden of deaths worldwide, mainly due to cardiovascular events and cancer.
The pathogenesis of these diseases is extremely complex, multifactorial, and only partially understood.
As the main metabolic organ, the liver is central to maintain whole body energetic homeostasis.
At the cellular level, mitochondria are the metabolic hub connecting and integrating all the main biochemical, hormonal, and inflammatory signaling pathways to fulfill the energetic and biosynthetic demand of the cell.
In the liver, mitochondria metabolism needs to cope with the energetic regulation of the whole body.
The nuclear receptors PPARs orchestrate lipid and glucose metabolism and are involved in a variety of diseases, from metabolic disorders to cancer.
In this review, focus is placed on the roles of PPARs in the regulation of liver mitochondrial metabolism in physiology and pathology, from NAFLD to HCC.
American Psychological Association (APA)
Mello, Tommaso& Materozzi, Maria& Galli, Andrea. 2016. PPARs and Mitochondrial Metabolism: From NAFLD to HCC. PPAR Research،Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1115341
Modern Language Association (MLA)
Mello, Tommaso…[et al.]. PPARs and Mitochondrial Metabolism: From NAFLD to HCC. PPAR Research No. 2016 (2016), pp.1-18.
https://search.emarefa.net/detail/BIM-1115341
American Medical Association (AMA)
Mello, Tommaso& Materozzi, Maria& Galli, Andrea. PPARs and Mitochondrial Metabolism: From NAFLD to HCC. PPAR Research. 2016. Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1115341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115341