Inducible Conditional Vascular-Specific Overexpression of Peroxisome Proliferator-Activated Receptor BetaDelta Leads to Rapid Cardiac Hypertrophy
Joint Authors
Wagner, Kay-Dietrich
Vukolic, Ana
Baudouy, Delphine
Michiels, Jean-François
Wagner, Nicole
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptors are nuclear receptors which function as ligand-activated transcription factors.
Among them, peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) is highly expressed in the heart and thought to have cardioprotective functions due to its beneficial effects in metabolic syndrome.
As we already showed that PPARβ/δ activation resulted in an enhanced cardiac angiogenesis and growth without impairment of heart function, we were interested to determine the effects of a specific activation of PPARβ/δ in the vasculature on cardiac performance under normal and in chronic ischemic heart disease conditions.
We analyzed the effects of a specific PPARβ/δ overexpression in endothelial cells on the heart using an inducible conditional vascular-specific mouse model.
We demonstrate that vessel-specific overexpression of PPARβ/δ induces rapid cardiac angiogenesis and growth with an increase in cardiomyocyte size.
Upon myocardial infarction, vascular overexpression of PPARβ/δ, despite the enhanced cardiac vessel formation, does not protect against chronic ischemic injury.
Our results suggest that the proper balance of PPARβ/δ activation in the different cardiac cell types is required to obtain beneficial effects on the outcome in chronic ischemic heart disease.
American Psychological Association (APA)
Wagner, Kay-Dietrich& Vukolic, Ana& Baudouy, Delphine& Michiels, Jean-François& Wagner, Nicole. 2016. Inducible Conditional Vascular-Specific Overexpression of Peroxisome Proliferator-Activated Receptor BetaDelta Leads to Rapid Cardiac Hypertrophy. PPAR Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1115350
Modern Language Association (MLA)
Wagner, Kay-Dietrich…[et al.]. Inducible Conditional Vascular-Specific Overexpression of Peroxisome Proliferator-Activated Receptor BetaDelta Leads to Rapid Cardiac Hypertrophy. PPAR Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1115350
American Medical Association (AMA)
Wagner, Kay-Dietrich& Vukolic, Ana& Baudouy, Delphine& Michiels, Jean-François& Wagner, Nicole. Inducible Conditional Vascular-Specific Overexpression of Peroxisome Proliferator-Activated Receptor BetaDelta Leads to Rapid Cardiac Hypertrophy. PPAR Research. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1115350
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115350