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Pioglitazone Protected against Cardiac Hypertrophy via Inhibiting AKTGSK3β and MAPK Signaling Pathways
Joint Authors
Tang, Qi-Zhu
Wei, Wen-Ying
Ma, Zhen-Guo
Xu, Si-Chi
Zhang, Ning
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Peroxisome proliferator activated receptor γ (PPARγ) has been closely involved in the process of cardiovascular diseases.
This study was to investigate whether pioglitazone (PIO), a PPARγ agonist, could protect against pressure overload-induced cardiac hypertrophy.
Mice were orally given PIO (2.5 mg/kg) from 1 week after aortic banding and continuing for 7 weeks.
The morphological examination and biochemical analysis were used to evaluate the effects of PIO.
Neonatal rat ventricular cardiomyocytes were also used to verify the protection of PIO against hypertrophy in vitro.
The results in our study demonstrated that PIO remarkably inhibited hypertrophic response induced by aortic banding in vivo.
Besides, PIO also suppressed cardiac fibrosis in vivo.
PIO treatment also inhibited the activation of protein kinase B (AKT)/glycogen synthase kinase-3β (GSK3β) and mitogen-activated protein kinase (MAPK) in the heart.
In addition, PIO alleviated angiotensin II-induced hypertrophic response in vitro.
In conclusion, PIO could inhibit cardiac hypertrophy via attenuation of AKT/GSK3β and MAPK pathways.
American Psychological Association (APA)
Wei, Wen-Ying& Ma, Zhen-Guo& Xu, Si-Chi& Zhang, Ning& Tang, Qi-Zhu. 2016. Pioglitazone Protected against Cardiac Hypertrophy via Inhibiting AKTGSK3β and MAPK Signaling Pathways. PPAR Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1115361
Modern Language Association (MLA)
Wei, Wen-Ying…[et al.]. Pioglitazone Protected against Cardiac Hypertrophy via Inhibiting AKTGSK3β and MAPK Signaling Pathways. PPAR Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1115361
American Medical Association (AMA)
Wei, Wen-Ying& Ma, Zhen-Guo& Xu, Si-Chi& Zhang, Ning& Tang, Qi-Zhu. Pioglitazone Protected against Cardiac Hypertrophy via Inhibiting AKTGSK3β and MAPK Signaling Pathways. PPAR Research. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1115361
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115361