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Feasibility of Topical Applications of Natural High-Concentration Capsaicinoid Solutions in Patients with Peripheral Neuropathic Pain: A Retrospective Analysis
Joint Authors
Quetin-Leclercq, Joëlle
Bauchy, Fanny
Mouraux, Andre
Deumens, Ronald
Leerink, Marjolein
Ulpiano Trillig, Antonio
le Polain de Waroux, Bernard
Steyaert, Arnaud
Forget, Patrice
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Capsaicin, one of several capsaicinoid compounds, is a potent TRPV1 agonist.
Topical application at high concentration (high concentration, >1%) induces a reversible disappearance of epidermal free nerve endings and is used to treat peripheral neuropathic pain (PNP).
While the benefit of low-concentration capsaicin remains controversial, the 8%-capsaicin patch (Qutenza®, 2010, Astellas, Netherlands) has shown its effectiveness.
This patch is, however, costly and natural high-concentration capsaicinoid solutions may represent a cheaper alternative to pure capsaicin.
Methods.
In this retrospective study, 149 patients were screened, 132 were included with a diagnosis of neuropathic pain, and eighty-four were retained in the final analyses (median age: 57.5 years [IQR25–75: 44.7–67.1], male/female: 30/54) with PNP who were treated with topical applications of natural high-concentration capsaicinoid solutions (total number of applications: 137).
Indications were postsurgical PNP (85.7%) and nonsurgical PNP (14.3%) (posttraumatic, HIV-related, postherpetic, and radicular PNP).
Objectives.
To assess the feasibility of topical applications of natural high-concentration capsaicinoid solutions for the treatment of PNP.
Results.
The median treated area was 250 cm2 [IQR25–75: 144–531].
The median amount of capsaicinoids was 55.1 mg [IQR25–75: 28.7–76.5] per plaster and the median concentration was 172.3 μg/cm2 [IQR25–75: 127.6–255.2].
Most patients had local adverse effects on the day of treatment, such as mild to moderate burning pain and erythema.
13.6–19.4% of the patients experienced severe pain or erythema.
Following treatment, 62.5% of patients reported a lower pain intensity or a smaller pain surface, and 35% reported a sustained pain relief lasting for at least 4 weeks.
Conclusion.
Analgesic topical treatment with natural high-concentration capsaicinoid is feasible and may represent a low cost alternative to alleviate PNP in clinical practice.
American Psychological Association (APA)
Bauchy, Fanny& Mouraux, Andre& Deumens, Ronald& Leerink, Marjolein& Ulpiano Trillig, Antonio& le Polain de Waroux, Bernard…[et al.]. 2016. Feasibility of Topical Applications of Natural High-Concentration Capsaicinoid Solutions in Patients with Peripheral Neuropathic Pain: A Retrospective Analysis. Pain Research and Management،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1115540
Modern Language Association (MLA)
Bauchy, Fanny…[et al.]. Feasibility of Topical Applications of Natural High-Concentration Capsaicinoid Solutions in Patients with Peripheral Neuropathic Pain: A Retrospective Analysis. Pain Research and Management No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1115540
American Medical Association (AMA)
Bauchy, Fanny& Mouraux, Andre& Deumens, Ronald& Leerink, Marjolein& Ulpiano Trillig, Antonio& le Polain de Waroux, Bernard…[et al.]. Feasibility of Topical Applications of Natural High-Concentration Capsaicinoid Solutions in Patients with Peripheral Neuropathic Pain: A Retrospective Analysis. Pain Research and Management. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1115540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115540