Novel Pattern of Iron Deposition in the Fascicula Nigrale in Patients with Parkinson’s Disease: A Pilot Study
Joint Authors
Dashtipour, Khashayar
Kani, Camellia
Kani, Kayvan
Peckham, Miriam E.
Holshouser, Barbara A.
Boscanin, Alex
Harder, Sheri L.
Source
Radiology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Purpose.
To determine whether the pattern of iron deposition in the fascicula nigrale in patients with Parkinson’s disease would be different from age-matched controls by utilizing quantitative susceptibility mapping to measure susceptibility change.
Methods.
MRIs of the brain were obtained from 34 subjects, 18 with Parkinson’s disease and 16 age- and gender-matched controls.
Regions of interest were drawn around the fascicula nigrale and substantia nigra using SWI mapping software by blinded investigators.
Statistical analyses were performed to determine susceptibility patterns of both of these regions.
Results.
Measurements showed significantly increased susceptibility in the substantia nigra in Parkinson’s patients and an increased rostral-caudal deposition of iron in the fascicula nigrale in all subjects.
This trend was exaggerated with significant correlation noted with increasing age in the Parkinson group.
Conclusion.
The pattern of an exaggerated iron deposition gradient of the fascicula nigrale in the Parkinson group could represent underlying tract dysfunction.
Significant correlation of increasing iron deposition with increasing age may be a cumulative effect, possibly related to disease duration.
American Psychological Association (APA)
Peckham, Miriam E.& Dashtipour, Khashayar& Holshouser, Barbara A.& Kani, Camellia& Boscanin, Alex& Kani, Kayvan…[et al.]. 2016. Novel Pattern of Iron Deposition in the Fascicula Nigrale in Patients with Parkinson’s Disease: A Pilot Study. Radiology Research and Practice،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115723
Modern Language Association (MLA)
Peckham, Miriam E.…[et al.]. Novel Pattern of Iron Deposition in the Fascicula Nigrale in Patients with Parkinson’s Disease: A Pilot Study. Radiology Research and Practice No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1115723
American Medical Association (AMA)
Peckham, Miriam E.& Dashtipour, Khashayar& Holshouser, Barbara A.& Kani, Camellia& Boscanin, Alex& Kani, Kayvan…[et al.]. Novel Pattern of Iron Deposition in the Fascicula Nigrale in Patients with Parkinson’s Disease: A Pilot Study. Radiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115723
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115723