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Trabectedin Followed by Irinotecan Can Stabilize Disease in Advanced Translocation-Positive Sarcomas with Acceptable Toxicity
Joint Authors
Herzog, J.
Klot-Heydenfeldt, F. von
Jabar, S.
Ranft, A.
Rossig, C.
Van den Brande, J.
Luettichau, I. von
Grohar, P. J.
Berdel, W. E.
Burdach, St.
Dirksen, Uta
D'Incalci, Maurizio
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Preclinical data indicate that trabectedin followed by irinotecan has strong synergistic effects on Ewing sarcoma.
This is presumably due to hypersensitization of the tumor cells to the camptothecin as an effect of trabectedin in addition to synergistic suppression of EWS-FLI1 downstream targets.
A strong effect was also reported in a human rhabdomyosarcoma xenograft.
Procedure.
Twelve patients with end-stage refractory translocation-positive sarcomas were treated with trabectedin followed by irinotecan within a compassionate use program.
Eight patients had Ewing sarcoma and four patients had other translocation-positive sarcomas.
Results.
Three-month survival rate was 0.75 after the start of this therapy.
One patient achieved a partial response according to RECIST criteria, five had stable disease, and the remaining six progressed through therapy.
The majority of patients experienced significant hematological toxicity (grades 3 and 4).
Reversible liver toxicity and diarrhea also occurred.
Conclusions.
Our experience with the combination of trabectedin followed with irinotecan in patients with advanced sarcomas showed promising results in controlling refractory solid tumors.
While the hematological toxicity was significant, it was reversible.
Quality of life during therapy was maintained.
These observations encourage a larger clinical trial.
American Psychological Association (APA)
Herzog, J.& Klot-Heydenfeldt, F. von& Jabar, S.& Ranft, A.& Rossig, C.& Dirksen, Uta…[et al.]. 2016. Trabectedin Followed by Irinotecan Can Stabilize Disease in Advanced Translocation-Positive Sarcomas with Acceptable Toxicity. Complexity،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1115785
Modern Language Association (MLA)
Herzog, J.…[et al.]. Trabectedin Followed by Irinotecan Can Stabilize Disease in Advanced Translocation-Positive Sarcomas with Acceptable Toxicity. Complexity No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1115785
American Medical Association (AMA)
Herzog, J.& Klot-Heydenfeldt, F. von& Jabar, S.& Ranft, A.& Rossig, C.& Dirksen, Uta…[et al.]. Trabectedin Followed by Irinotecan Can Stabilize Disease in Advanced Translocation-Positive Sarcomas with Acceptable Toxicity. Complexity. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1115785
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115785