Neurophysiology for Detection of High Risk for Psychosis
Joint Authors
Pantlin, Lara N.
Davalos, Deana
Source
Schizophrenia Research and Treatment
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Schizophrenia is a complex and often disabling disorder that is characterized by a wide range of social, emotional, and cognitive deficits.
Increasing research suggests that the greatest social and cognitive therapeutic impact comes from early identification.
The present study applied a well-established neurophysiological paradigm in the schizophrenia literature, mismatch negativity (MMN), to college students identified as high risk (HR) for psychosis to investigate MMN as a potential biomarker for the onset of psychosis.
The hypothesis was that HR would exhibit attenuated MMN amplitudes compared to controls, as has been established in individuals with chronic schizophrenia.
Participants ( N = 121 ) were separated into Group 1 (controls) ( n 1 = 72 ) and Group 2 (HR) ( n 2 = 49 ) based on the established cutoff score of the 16-item Prodromal Questionnaire.
Participants then completed a time based MMN paradigm during which brain activity was recorded with EEG.
For all electrode locations, controls demonstrated significantly more negative amplitudes than HR ( C z : F ( 1,119 ) = 8.09 , p = .
005 ; F z : F ( 1 , 119 ) = 5.74 , p = .
018 ; P z : F ( 1,119 ) = 5.88 , p = .
017 ).
Results suggested that MMN may assist in identifying those who appear high-functioning but may be at risk for later development of psychosis or cognitive and psychological difficulties associated with psychosis.
American Psychological Association (APA)
Pantlin, Lara N.& Davalos, Deana. 2016. Neurophysiology for Detection of High Risk for Psychosis. Schizophrenia Research and Treatment،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1115813
Modern Language Association (MLA)
Pantlin, Lara N.& Davalos, Deana. Neurophysiology for Detection of High Risk for Psychosis. Schizophrenia Research and Treatment No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1115813
American Medical Association (AMA)
Pantlin, Lara N.& Davalos, Deana. Neurophysiology for Detection of High Risk for Psychosis. Schizophrenia Research and Treatment. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1115813
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115813