![](/images/graphics-bg.png)
The Therapeutic Targets of miRNA in Hepatic Cancer Stem Cells
Joint Authors
Izzo, Francesco
Bimonte, Sabrina
Barbieri, Antonio
Giudice, Aldo
del Vecchio, Vitale
Falco, Michela
Leongito, Maddalena
Palaia, Raffaele
Di Giacomo, Raimondo
Granata, Vincenza
Albino, Vittorio
Petrillo, Antonella
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-28
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide malignancy and the third leading cause of cancer death in patients.
Several studies demonstrated that hepatic cancer stem cells (HCSCs), also called tumor-initiating cells, are involved in regulation of HCC initiation, tumor progression, metastasis development, and drug resistance.
Despite the extensive research, the underlying mechanisms by which HCSCs are regulated remain still unclear.
MicroRNAs (miRNAs) are able to regulate a lot of biological processes such as self-renewal and pluripotency of HCSCs, representing a new promising strategy for treatment of HCC chemotherapy-resistant tumors.
In this review, we synthesize the latest findings on therapeutic regulation of HCSCs by miRNAs, in order to highlight the perspective of novel miRNA-based anticancer therapies for HCC treatment.
American Psychological Association (APA)
Bimonte, Sabrina& Leongito, Maddalena& Barbieri, Antonio& del Vecchio, Vitale& Falco, Michela& Giudice, Aldo…[et al.]. 2016. The Therapeutic Targets of miRNA in Hepatic Cancer Stem Cells. Stem Cells International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1115963
Modern Language Association (MLA)
Bimonte, Sabrina…[et al.]. The Therapeutic Targets of miRNA in Hepatic Cancer Stem Cells. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1115963
American Medical Association (AMA)
Bimonte, Sabrina& Leongito, Maddalena& Barbieri, Antonio& del Vecchio, Vitale& Falco, Michela& Giudice, Aldo…[et al.]. The Therapeutic Targets of miRNA in Hepatic Cancer Stem Cells. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1115963
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115963