Extracellular Vesicles: Evolving Factors in Stem Cell Biology
Joint Authors
Nawaz, Muhammad
Fatima, Farah
Vallabhaneni, Krishna C.
Penfornis, Patrice
Valadi, Hadi
Ekström, Karin
Kholia, Sharad
Whitt, Jason D.
Fernandes, Joseph D.
Squire, Jeremy A.
Camussi, Giovanni
Pochampally, Radhika
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-16
Country of Publication
Egypt
No. of Pages
17
Abstract EN
Stem cells are proposed to continuously secrete trophic factors that potentially serve as mediators of autocrine and paracrine activities, associated with reprogramming of the tumor microenvironment, tissue regeneration, and repair.
Hitherto, significant efforts have been made to understand the level of underlying paracrine activities influenced by stem cell secreted trophic factors, as little is known about these interactions.
Recent findings, however, elucidate this role by reporting the effects of stem cell derived extracellular vesicles (EVs) that mimic the phenotypes of the cells from which they originate.
Exchange of genetic information utilizing persistent bidirectional communication mediated by stem cell-EVs could regulate stemness, self-renewal, and differentiation in stem cells and their subpopulations.
This review therefore discusses stem cell-EVs as evolving communication factors in stem cell biology, focusing on how they regulate cell fates by inducing persistent and prolonged genetic reprogramming of resident cells in a paracrine fashion.
In addition, we address the role of stem cell-secreted vesicles in shaping the tumor microenvironment and immunomodulation and in their ability to stimulate endogenous repair processes during tissue damage.
Collectively, these functions ensure an enormous potential for future therapies.
American Psychological Association (APA)
Nawaz, Muhammad& Fatima, Farah& Vallabhaneni, Krishna C.& Penfornis, Patrice& Valadi, Hadi& Ekström, Karin…[et al.]. 2015. Extracellular Vesicles: Evolving Factors in Stem Cell Biology. Stem Cells International،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1115964
Modern Language Association (MLA)
Nawaz, Muhammad…[et al.]. Extracellular Vesicles: Evolving Factors in Stem Cell Biology. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1115964
American Medical Association (AMA)
Nawaz, Muhammad& Fatima, Farah& Vallabhaneni, Krishna C.& Penfornis, Patrice& Valadi, Hadi& Ekström, Karin…[et al.]. Extracellular Vesicles: Evolving Factors in Stem Cell Biology. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1115964
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115964