Secretome of Olfactory Mucosa Mesenchymal Stem Cell, a Multiple Potential Stem Cell
Joint Authors
Zhao, Zhenyu
Ge, Lite
Jiang, Miao
Duan, Da
Wang, Zijun
Qi, Linyu
Teng, Xiaohua
Wang, Lei
Zhuo, Yi
Chen, Ping
He, Xijing
Lu, Ming
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-01
Country of Publication
Egypt
No. of Pages
16
Abstract EN
Nasal olfactory mucosa mesenchymal stem cells (OM-MSCs) have the ability to promote regeneration in the nervous system in vivo.
Moreover, with view to the potential for clinical application, OM-MSCs have the advantage of being easily accessible from patients and transplantable in an autologous manner, thus eliminating immune rejection and contentious ethical issues.
So far, most studies have been focused on the role of OM-MSCs in central nervous system replacement.
However, the secreted proteomics of OM-MSCs have not been reported yet.
Here, proteins secreted by OM-MSCs cultured in serum-free conditions were separated on SDS-PAGE and identified by LC-MS/MS.
As a result, a total of 274 secreted proteins were identified.
These molecules are known to be important in neurotrophy, angiogenesis, cell growth, differentiation, and apoptosis, and inflammation which were highly correlated with the repair of central nervous system.
The proteomic profiling of the OM-MSCs secretome might provide new insights into their nature in the neural recovery.
However, proteomic analysis for clinical biomarkers of OM-MSCs needs to be further studied.
American Psychological Association (APA)
Ge, Lite& Jiang, Miao& Duan, Da& Wang, Zijun& Qi, Linyu& Teng, Xiaohua…[et al.]. 2016. Secretome of Olfactory Mucosa Mesenchymal Stem Cell, a Multiple Potential Stem Cell. Stem Cells International،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1115982
Modern Language Association (MLA)
Ge, Lite…[et al.]. Secretome of Olfactory Mucosa Mesenchymal Stem Cell, a Multiple Potential Stem Cell. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1115982
American Medical Association (AMA)
Ge, Lite& Jiang, Miao& Duan, Da& Wang, Zijun& Qi, Linyu& Teng, Xiaohua…[et al.]. Secretome of Olfactory Mucosa Mesenchymal Stem Cell, a Multiple Potential Stem Cell. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1115982
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115982