Proangiogenic Features of Mesenchymal Stem Cells and Their Therapeutic Applications
Joint Authors
Han, Zhi-bo
Han, Zhong Chao
Tao, Hongyan
Li, Zongjin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Mesenchymal stem cells (MSCs) have shown their therapeutic potency for treatment of cardiovascular diseases owing to their low immunogenicity, ease of isolation and expansion, and multipotency.
As multipotent progenitors, MSCs have revealed their ability to differentiate into various cell types and could promote endogenous angiogenesis via microenvironmental modulation.
Studies on cardiovascular diseases have demonstrated that transplanted MSCs could engraft at the injured sites and differentiate into cardiomyocytes and endothelial cells as well.
Accordingly, several clinical trials using MSCs have been performed and revealed that MSCs may improve relevant clinical parameters in patients with vascular diseases.
To fully comprehend the characteristics of MSCs, understanding their intrinsic property and associated modulations in tuning their behaviors as well as functions is indispensable for future clinical translation of MSC therapy.
This review will focus on recent progresses on endothelial differentiation and potential clinical application of MSCs, with emphasis on therapeutic angiogenesis for treatment of cardiovascular diseases.
American Psychological Association (APA)
Tao, Hongyan& Han, Zhi-bo& Han, Zhong Chao& Li, Zongjin. 2016. Proangiogenic Features of Mesenchymal Stem Cells and Their Therapeutic Applications. Stem Cells International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116000
Modern Language Association (MLA)
Tao, Hongyan…[et al.]. Proangiogenic Features of Mesenchymal Stem Cells and Their Therapeutic Applications. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1116000
American Medical Association (AMA)
Tao, Hongyan& Han, Zhi-bo& Han, Zhong Chao& Li, Zongjin. Proangiogenic Features of Mesenchymal Stem Cells and Their Therapeutic Applications. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116000
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116000