Regenerative Potential of Mesenchymal Stromal Cells: Age-Related Changes

Joint Authors

Conget, Paulette
Bruna, Flavia
Contador, David
Erranz, Benjamín
Sossa, Claudia L.
Arango-Rodríguez, Martha L.

Source

Stem Cells International

Issue

Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-15, 15 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-05-09

Country of Publication

Egypt

No. of Pages

15

Abstract EN

Preclinical and clinical studies have shown that a therapeutic effect results from mesenchymal stromal cells (MSCs) transplant.

No systematic information is currently available regarding whether donor age modifies MSC regenerative potential on cutaneous wound healing.

Here, we evaluate whether donor age influences this potential.

Two different doses of bone marrow MSCs (BM-MSCs) from young, adult, or old mouse donors or two doses of their acellular derivatives mesenchymal stromal cells (acd-MSCs) were intradermally injected around wounds in the midline of C57BL/6 mice.

Every two days, wound healing was macroscopically assessed (wound closure) and microscopically assessed (reepithelialization, dermal-epidermal junction, skin appendage regeneration, granulation tissue, leukocyte infiltration, and density dermal collagen fibers) after 12 days from MSC transplant.

Significant differences in the wound closure kinetic, quality, and healing of skin regenerated were observed in lesions which received BM-MSCs from different ages or their acd-MSCs compared to lesions which received vehicle.

Nevertheless, our data shows that adult’s BM-MSCs or their acd-MSCs were the most efficient for recovery of most parameters analyzed.

Our data suggest that MSC efficacy was negatively affected by donor age, where the treatment with adult’s BM-MSCs or their acd-MSCs in cutaneous wound promotes a better tissue repair/regeneration.

This is due to their paracrine factors secretion.

American Psychological Association (APA)

Bruna, Flavia& Contador, David& Conget, Paulette& Erranz, Benjamín& Sossa, Claudia L.& Arango-Rodríguez, Martha L.. 2016. Regenerative Potential of Mesenchymal Stromal Cells: Age-Related Changes. Stem Cells International،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1116047

Modern Language Association (MLA)

Bruna, Flavia…[et al.]. Regenerative Potential of Mesenchymal Stromal Cells: Age-Related Changes. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1116047

American Medical Association (AMA)

Bruna, Flavia& Contador, David& Conget, Paulette& Erranz, Benjamín& Sossa, Claudia L.& Arango-Rodríguez, Martha L.. Regenerative Potential of Mesenchymal Stromal Cells: Age-Related Changes. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1116047

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1116047