Mimicking Neural Stem Cell Niche by Biocompatible Substrates
Joint Authors
Regalado-Santiago, Citlalli
Juárez-Aguilar, Enrique
Olivares-Hernández, Juan David
Tamariz, Elisa
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
15
Abstract EN
Neural stem cells (NSCs) participate in the maintenance, repair, and regeneration of the central nervous system.
During development, the primary NSCs are distributed along the ventricular zone of the neural tube, while, in adults, NSCs are mainly restricted to the subependymal layer of the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus.
The circumscribed areas where the NSCs are located contain the secreted proteins and extracellular matrix components that conform their niche.
The interplay among the niche elements and NSCs determines the balance between stemness and differentiation, quiescence, and proliferation.
The understanding of niche characteristics and how they regulate NSCs activity is critical to building in vitro models that include the relevant components of the in vivo niche and to developing neuroregenerative approaches that consider the extracellular environment of NSCs.
This review aims to examine both the current knowledge on neurogenic niche and how it is being used to develop biocompatible substrates for the in vitro and in vivo mimicking of extracellular NSCs conditions.
American Psychological Association (APA)
Regalado-Santiago, Citlalli& Juárez-Aguilar, Enrique& Olivares-Hernández, Juan David& Tamariz, Elisa. 2016. Mimicking Neural Stem Cell Niche by Biocompatible Substrates. Stem Cells International،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1116060
Modern Language Association (MLA)
Regalado-Santiago, Citlalli…[et al.]. Mimicking Neural Stem Cell Niche by Biocompatible Substrates. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1116060
American Medical Association (AMA)
Regalado-Santiago, Citlalli& Juárez-Aguilar, Enrique& Olivares-Hernández, Juan David& Tamariz, Elisa. Mimicking Neural Stem Cell Niche by Biocompatible Substrates. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1116060
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116060