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Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models
Joint Authors
Sontakke, Pallavi
Jaques, Jenny
Vellenga, Edo
Schuringa, Jan Jacob
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-25
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Over the past years, a wide variety of in vivo mouse models have been generated in order to unravel the molecular pathology of Chronic Myeloid Leukemia (CML) and to develop and improve therapeutic approaches.
These models range from (conditional) transgenic models, knock-in models, and murine bone marrow retroviral transduction models followed by transplantation.
With the advancement of immunodeficient xenograft models, it has become possible to use human stem/progenitor cells for in vivo studies as well as cells directly derived from CML patients.
These models not only mimic CML but also have been instrumental in uncovering various fundamental mechanisms of CML disease progression and tyrosine kinase inhibitor (TKI) resistance.
With the availability of iPSC technology, it has become feasible to derive, maintain, and expand CML subclones that are at least genetically identical to those in patients.
The following review provides an overview of all murine as well as human xenograft models for CML established till date.
American Psychological Association (APA)
Sontakke, Pallavi& Jaques, Jenny& Vellenga, Edo& Schuringa, Jan Jacob. 2016. Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models. Stem Cells International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1116075
Modern Language Association (MLA)
Sontakke, Pallavi…[et al.]. Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1116075
American Medical Association (AMA)
Sontakke, Pallavi& Jaques, Jenny& Vellenga, Edo& Schuringa, Jan Jacob. Modeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft Models. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1116075
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116075