Primordial Germ Cells: Current Knowledge and Perspectives
Joint Authors
Lako, Majlinda
Nikolic, Aleksandar
Volarevic, Vladislav
Armstrong, Lyle
Stojkovic, Miodrag
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-09
Country of Publication
Egypt
No. of Pages
8
Abstract EN
Infertility is a condition that occurs very frequently and understanding what defines normal fertility is crucial to helping patients.
Causes of infertility are numerous and the treatment often does not lead to desired pregnancy especially when there is a lack of functional gametes.
In humans, the primordial germ cell (PGC) is the primary undifferentiated stem cell type that will differentiate towards gametes: spermatozoa or oocytes.
With the development of stem cell biology and differentiation protocols, PGC can be obtained from pluripotent stem cells providing a new therapeutic possibility to treat infertile couples.
Recent studies demonstrated that viable mouse pups could be obtained from in vitro differentiated stem cells suggesting that translation of these results to human is closer.
Therefore, the aim of this review is to summarize current knowledge about PGC indicating the perspective of their use in both research and medical application for the treatment of infertility.
American Psychological Association (APA)
Nikolic, Aleksandar& Volarevic, Vladislav& Armstrong, Lyle& Lako, Majlinda& Stojkovic, Miodrag. 2015. Primordial Germ Cells: Current Knowledge and Perspectives. Stem Cells International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116122
Modern Language Association (MLA)
Nikolic, Aleksandar…[et al.]. Primordial Germ Cells: Current Knowledge and Perspectives. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1116122
American Medical Association (AMA)
Nikolic, Aleksandar& Volarevic, Vladislav& Armstrong, Lyle& Lako, Majlinda& Stojkovic, Miodrag. Primordial Germ Cells: Current Knowledge and Perspectives. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116122
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116122