Metaboloepigenetic Regulation of Pluripotent Stem Cells

Joint Authors

Harvey, Alexandra J.
Rathjen, Joy
Gardner, David K.

Source

Stem Cells International

Issue

Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-15, 15 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-12-29

Country of Publication

Egypt

No. of Pages

15

Abstract EN

The differentiation of pluripotent stem cells is associated with extensive changes in metabolism, as well as widespread remodeling of the epigenetic landscape.

Epigenetic regulation is essential for the modulation of differentiation, being responsible for cell type specific gene expression patterns through the modification of DNA and histones, thereby establishing cell identity.

Each cell type has its own idiosyncratic pattern regarding the use of specific metabolic pathways.

Rather than simply being perceived as a means of generating ATP and building blocks for cell growth and division, cellular metabolism can directly influence cellular regulation and the epigenome.

Consequently, the significance of nutrients and metabolites as regulators of differentiation is central to understanding how cells interact with their immediate environment.

This review serves to integrate studies on pluripotent stem cell metabolism, and the regulation of DNA methylation and acetylation and identifies areas in which current knowledge is limited.

American Psychological Association (APA)

Harvey, Alexandra J.& Rathjen, Joy& Gardner, David K.. 2015. Metaboloepigenetic Regulation of Pluripotent Stem Cells. Stem Cells International،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1116145

Modern Language Association (MLA)

Harvey, Alexandra J.…[et al.]. Metaboloepigenetic Regulation of Pluripotent Stem Cells. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1116145

American Medical Association (AMA)

Harvey, Alexandra J.& Rathjen, Joy& Gardner, David K.. Metaboloepigenetic Regulation of Pluripotent Stem Cells. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1116145

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1116145