The Modulatory Effects of Mesenchymal Stem Cells on Osteoclastogenesis
Joint Authors
Sharaf-Eldin, Wessam E.
Abu-Shahba, Nourhan
Mahmoud, Marwa
El-Badri, Nagwa
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-28
Country of Publication
Egypt
No. of Pages
13
Abstract EN
The effect of mesenchymal stem cells (MSCs) on bone formation has been extensively demonstrated through several in vitro and in vivo studies.
However, few studies addressed the effect of MSCs on osteoclastogenesis and bone resorption.
Under physiological conditions, MSCs support osteoclastogenesis through producing the main osteoclastogenic cytokines, RANKL and M-CSF.
However, during inflammation, MSCs suppress osteoclast formation and activity, partly via secretion of the key anti-osteoclastogenic factor, osteoprotegerin (OPG).
In vitro, co-culture of MSCs with osteoclasts in the presence of high concentrations of osteoclast-inducing factors might reflect the in vivo inflammatory pathology and prompt MSCs to exert an osteoclastogenic suppressive effect.
MSCs thus seem to have a dual effect, by stimulating or inhibiting osteoclastogenesis, depending on the inflammatory milieu.
This effect of MSCs on osteoclast formation seems to mirror the effect of MSCs on other immune cells, and may be exploited for the therapeutic potential of MSCs in bone loss associated inflammatory diseases.
American Psychological Association (APA)
Sharaf-Eldin, Wessam E.& Abu-Shahba, Nourhan& Mahmoud, Marwa& El-Badri, Nagwa. 2015. The Modulatory Effects of Mesenchymal Stem Cells on Osteoclastogenesis. Stem Cells International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116152
Modern Language Association (MLA)
Sharaf-Eldin, Wessam E.…[et al.]. The Modulatory Effects of Mesenchymal Stem Cells on Osteoclastogenesis. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1116152
American Medical Association (AMA)
Sharaf-Eldin, Wessam E.& Abu-Shahba, Nourhan& Mahmoud, Marwa& El-Badri, Nagwa. The Modulatory Effects of Mesenchymal Stem Cells on Osteoclastogenesis. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116152
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116152