Identification of Stem-Like Cells in Atrial Myxoma by Markers CD44, CD19, and CD45
Joint Authors
Qi, Xin
Song, Xianghe
Liu, Danni
Cui, Jian
Zhou, Manqian
Liu, Na
Wang, Hui
Li, Zongjin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-27
Country of Publication
Egypt
No. of Pages
5
Abstract EN
Atrial myxoma is the most frequent tumor arising mainly in atrial septum and its origin remains uncertain.
It has been reported that a subpopulation of stem-like cells are present in benign tumors and responsible for tumor initiation and maintenance.
In this study, we investigated whether stem-like cells could contribute to the atrial cardiac myxoma.
Immunohistology data confirmed that a population of cells bearing the surface markers CD19, CD45, and CD44 resided in a mucopolysaccharide-rich matrix of myxoma.
Moreover, we isolated myxoma cells with phase-bright culture method and confirmed that myxoma derived cells express robust level of CD19, CD45, and CD44.
Furthermore, the pluripotency of this population of cells also was validated by cardiomyocytes and smooth muscle cells differentiation in vitro.
Our results indicate that primary cardiac myxoma may arise from mesenchymal stem cells with the ability to generate tumors with multilineage differentiation.
In conclusion, this study for the first time verified that stem-like cells are present in atrial myxoma and this population of cells may have the capacity for myxoma initiation and progression.
American Psychological Association (APA)
Song, Xianghe& Liu, Danni& Cui, Jian& Zhou, Manqian& Wang, Hui& Liu, Na…[et al.]. 2016. Identification of Stem-Like Cells in Atrial Myxoma by Markers CD44, CD19, and CD45. Stem Cells International،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1116182
Modern Language Association (MLA)
Song, Xianghe…[et al.]. Identification of Stem-Like Cells in Atrial Myxoma by Markers CD44, CD19, and CD45. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1116182
American Medical Association (AMA)
Song, Xianghe& Liu, Danni& Cui, Jian& Zhou, Manqian& Wang, Hui& Liu, Na…[et al.]. Identification of Stem-Like Cells in Atrial Myxoma by Markers CD44, CD19, and CD45. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1116182
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116182