Modeling Neurological Disease by Rapid Conversion of Human Urine Cells into Functional Neurons
Joint Authors
Wang, Zhongfeng
Zhang, Shu-Zhen
Ma, Li-Xiang
Qian, Wen-Jing
Li, Hong-Fu
Wang, Hong-Xia
Wu, Zhi-Ying
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-07
Country of Publication
Egypt
No. of Pages
8
Abstract EN
Somatic cells can be directly converted into functional neurons by ectopic expression of defined factors and/or microRNAs.
Since the first report of conversion mouse embryonic fibroblasts into functional neurons, the postnatal mouse, and human fibroblasts, astroglia, hepatocytes, and pericyte-derived cells have been converted into functional dopaminergic and motor neurons both in vitro and in vivo.
However, it is invasive to get all these materials.
In the current study, we provide a noninvasive approach to obtain directly reprogrammed functional neurons by overexpression of the transcription factors Ascl1, Brn2, NeuroD, c-Myc, and Myt1l in human urine cells.
These induced neuronal (iN) cells could express multiple neuron-specific proteins and generate action potentials.
Moreover, urine cells from Wilson’s disease (WD) patient could also be directly converted into neurons.
In conclusion, generation of iN cells from nonneural lineages is a feasible and befitting approach for neurological disease modeling.
American Psychological Association (APA)
Zhang, Shu-Zhen& Ma, Li-Xiang& Qian, Wen-Jing& Li, Hong-Fu& Wang, Zhongfeng& Wang, Hong-Xia…[et al.]. 2015. Modeling Neurological Disease by Rapid Conversion of Human Urine Cells into Functional Neurons. Stem Cells International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116217
Modern Language Association (MLA)
Zhang, Shu-Zhen…[et al.]. Modeling Neurological Disease by Rapid Conversion of Human Urine Cells into Functional Neurons. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1116217
American Medical Association (AMA)
Zhang, Shu-Zhen& Ma, Li-Xiang& Qian, Wen-Jing& Li, Hong-Fu& Wang, Zhongfeng& Wang, Hong-Xia…[et al.]. Modeling Neurological Disease by Rapid Conversion of Human Urine Cells into Functional Neurons. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116217
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116217