![](/images/graphics-bg.png)
Endothelial Progenitor Cell Migration-Enhancing Factors in the Secretome of Placental-Derived Mesenchymal Stem Cells
Joint Authors
Issaragrisil, S.
Roytrakul, Sittiruk
Kamprom, Witchayaporn
Kheolamai, Pakpoom
Supokawej, Aungkura
Wattanapanitch, Methichit
Laowtammathron, Chuti
U-pratya, Yaowalak
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
13
Abstract EN
Therapeutic potentials of mesenchymal stem cells (MSCs) depend largely on their ability to secrete cytokines or factors that modulate immune response, enhance cell survival, and induce neovascularization in the target tissues.
We studied the secretome profile of gestational tissue-derived MSCs and their effects on functions of endothelial progenitor cells (EPCs), another angiogenic cell type that plays an important role during the neovascularization.
MSCs derived from placental tissues (PL-MSCs) significantly enhanced EPC migration while BM-MSCs, which are the standard source of MSCs for various clinical applications, did not.
By using protein fractionation and mass spectrometry analysis, we identified several novel candidates for EPC migration enhancing factor in PL-MSCs secretome that could be used to enhance neovascularization in the injured/ischemic tissues.
We recommend that the strategy developed in our study could be used to systematically identify therapeutically useful molecules in the secretomes of other MSC sources for the clinical applications.
American Psychological Association (APA)
Kamprom, Witchayaporn& Kheolamai, Pakpoom& U-pratya, Yaowalak& Supokawej, Aungkura& Wattanapanitch, Methichit& Laowtammathron, Chuti…[et al.]. 2016. Endothelial Progenitor Cell Migration-Enhancing Factors in the Secretome of Placental-Derived Mesenchymal Stem Cells. Stem Cells International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116234
Modern Language Association (MLA)
Kamprom, Witchayaporn…[et al.]. Endothelial Progenitor Cell Migration-Enhancing Factors in the Secretome of Placental-Derived Mesenchymal Stem Cells. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1116234
American Medical Association (AMA)
Kamprom, Witchayaporn& Kheolamai, Pakpoom& U-pratya, Yaowalak& Supokawej, Aungkura& Wattanapanitch, Methichit& Laowtammathron, Chuti…[et al.]. Endothelial Progenitor Cell Migration-Enhancing Factors in the Secretome of Placental-Derived Mesenchymal Stem Cells. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116234
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116234