The New Role of CD163 in the Differentiation of Bone Marrow Stromal Cells into Vascular Endothelial-Like Cells
Joint Authors
Lu, Wei
Su, Le
Yu, Zhezheng
Zhang, Shangli
Miao, Junying
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Bone marrow stromal cells (BMSCs) can differentiate into vascular endothelial cells (VECs).
It is regarded as an important solution to cure many diseases, such as ischemic diseases and diabetes.
However, the mechanisms underlying BMSC differentiation into VECs are not well understood.
Recent reports showed that CD163 expression was associated with angiogenesis.
In this study, overexpression of CD163 in BMSCs elevated the protein level of the endothelial-associated markers CD31, Flk-1, eNOS, and VE-cadherin, significantly increased the proportion of Alexa Fluor 488-acetylated-LDL-positive VECs, and promoted angiogenesis on Matrigel.
Furthermore, we demonstrated that CD163 acted downstream homeobox containing 1 (Hmbox1) and upstream fibroblast growth factor 2 (FGF-2).
These data suggested that CD163 was involved in Hmbox1/CD163/FGF-2 signal pathway in BMSC differentiation into vascular endothelial-like cells.
We found a new signal pathway and a novel target for further investigating the gene control of BMSC differentiation into a VEC lineage.
American Psychological Association (APA)
Lu, Wei& Su, Le& Yu, Zhezheng& Zhang, Shangli& Miao, Junying. 2016. The New Role of CD163 in the Differentiation of Bone Marrow Stromal Cells into Vascular Endothelial-Like Cells. Stem Cells International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1116245
Modern Language Association (MLA)
Lu, Wei…[et al.]. The New Role of CD163 in the Differentiation of Bone Marrow Stromal Cells into Vascular Endothelial-Like Cells. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1116245
American Medical Association (AMA)
Lu, Wei& Su, Le& Yu, Zhezheng& Zhang, Shangli& Miao, Junying. The New Role of CD163 in the Differentiation of Bone Marrow Stromal Cells into Vascular Endothelial-Like Cells. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1116245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116245