The Use of Human Adipose-Derived Stem Cells in the Treatment of Physiological and Pathological Vulvar Dystrophies
Joint Authors
Ceccarelli, Simona
Onesti, Maria Giuseppina
Carella, Sara
Scuderi, Nicolo
Marchese, Cinzia
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-10
Country of Publication
Egypt
No. of Pages
6
Abstract EN
“Vulvar dystrophy” is characterized by chronic alterations of vulvar trophism, occurring in both physiological (menopause) and pathological (lichen sclerosus, vulvar graft-versus-host disease) conditions.
Associated symptoms are itching, burning, dyspareunia and vaginal dryness.
Current treatments often do not imply a complete remission of symptoms.
Adipose-Derived Stem Cells (ADSCs) injection represents a valid alternative therapy to enhance trophism and tone of dystrophic tissues.
We evaluated efficacy of ADSCs-based therapy in the dystrophic areas.
From February to April 2013 we enrolled 8 patients with vulvar dystrophy.
A biopsy specimen was performed before and after treatment.
Digital photographs were taken at baseline and during the follow-up.
Pain was detected with Visual Analogue Scale and sexual function was evaluated with Female Sexual Function Index.
All patients received 2 treatments in 3 months.
Follow-up was at 1 week , 1 and 3 months, and 1 and 2 years.
We obtained a significant vulvar trophism enhancement in all patients, who reported pain reduction and sexual function improvement.
Objective exam with speculum was easy to perform after treatment.
We believe ADSCs-based therapy finds its application in the treatment of vulvar dystrophies, since ADSCs could induce increased vascularization due to their angiogenic properties and tissue trophism improvement thanks to their eutrophic effect.
American Psychological Association (APA)
Onesti, Maria Giuseppina& Carella, Sara& Ceccarelli, Simona& Marchese, Cinzia& Scuderi, Nicolo. 2016. The Use of Human Adipose-Derived Stem Cells in the Treatment of Physiological and Pathological Vulvar Dystrophies. Stem Cells International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1116253
Modern Language Association (MLA)
Onesti, Maria Giuseppina…[et al.]. The Use of Human Adipose-Derived Stem Cells in the Treatment of Physiological and Pathological Vulvar Dystrophies. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1116253
American Medical Association (AMA)
Onesti, Maria Giuseppina& Carella, Sara& Ceccarelli, Simona& Marchese, Cinzia& Scuderi, Nicolo. The Use of Human Adipose-Derived Stem Cells in the Treatment of Physiological and Pathological Vulvar Dystrophies. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1116253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116253