Genetic Background of Immune Complications after Allogeneic Hematopoietic Stem Cell Transplantation in Children
Joint Authors
Pietrzyk, Jacek Józef
Fijorek, Kamil
Skoczen, Szymon
Grabowska, Agnieszka
Strojny, Wojciech
Klus-Kwiecinska, Kinga
Siedlar, Maciej
Balwierz, Walentyna
Bik-Multanowski, Mirosław
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
6
Abstract EN
Immune reactions are among the most serious complications observed after hematopoietic stem cell transplantation (HSCT) in children.
Microarray technique allows for simultaneous assessment of expression of nearly all human genes.
The objective of the study was to compare the whole genome expression in children before and after HSCT.
A total of 33 children referred for HSCT were enrolled in the study.
In 70% of the patients HSCT was performed for the treatment of neoplasms.
Blood samples were obtained before HSCT and six months after the procedure.
Subsequently, the whole genome expression was assessed in leukocytes using GeneChip Human Gene 1.0 ST microarray.
The analysis of genomic profiles before and after HSCT revealed altered expression of 124 genes.
Pathway enrichment analysis revealed upregulation of five pathways after HSCT: allograft rejection, graft-versus-host disease, type I diabetes mellitus, autoimmune thyroid disease, and viral myocarditis.
The activation of those pathways seems to be related to immune reactions commonly observed after HSCT.
Our results contribute to better understanding of the genomic background of the immunologic complications of HSCT.
American Psychological Association (APA)
Skoczen, Szymon& Bik-Multanowski, Mirosław& Pietrzyk, Jacek Józef& Grabowska, Agnieszka& Fijorek, Kamil& Strojny, Wojciech…[et al.]. 2016. Genetic Background of Immune Complications after Allogeneic Hematopoietic Stem Cell Transplantation in Children. Stem Cells International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1116264
Modern Language Association (MLA)
Skoczen, Szymon…[et al.]. Genetic Background of Immune Complications after Allogeneic Hematopoietic Stem Cell Transplantation in Children. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1116264
American Medical Association (AMA)
Skoczen, Szymon& Bik-Multanowski, Mirosław& Pietrzyk, Jacek Józef& Grabowska, Agnieszka& Fijorek, Kamil& Strojny, Wojciech…[et al.]. Genetic Background of Immune Complications after Allogeneic Hematopoietic Stem Cell Transplantation in Children. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1116264
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116264