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Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers
Joint Authors
Li, Junjun
Minami, Itsunari
Yu, Leqian
Tsuji, Kiyotaka
Nakajima, Minako
Qiao, Jing
Suzuki, Masato
Shimono, Ken
Nakatsuji, Norio
Kotera, Hitetoshi
Liu, Li
Chen, Yong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-29
Country of Publication
Egypt
No. of Pages
9
Abstract EN
Human induced pluripotent stem cell (hiPSC) derived cardiomyocytes (CMs) hold high potential for use in drug assessment and myocardial regeneration.
To create tissue-like constructs of CMs for extracellular monitoring, we placed aligned fibers (AFs) on the surface of a microelectrode array and then seeded hiPSC-CMs for subsequent monitoring for 14 days.
As expected, the CMs organized into anisotropic and matured tissue and the extracellular recordings showed reduced premature beating higher signal amplitude and a higher probability of T-wave detection as compared to the culture without fibers.
The CMs on the aligned fibers samples also exhibited anisotropic propagation of the field potential.
These results therefore suggest that the hiPSC-CMs cultured on AFs can be used more reliably for cell based assays.
American Psychological Association (APA)
Li, Junjun& Minami, Itsunari& Yu, Leqian& Tsuji, Kiyotaka& Nakajima, Minako& Qiao, Jing…[et al.]. 2016. Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers. Stem Cells International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1116266
Modern Language Association (MLA)
Li, Junjun…[et al.]. Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1116266
American Medical Association (AMA)
Li, Junjun& Minami, Itsunari& Yu, Leqian& Tsuji, Kiyotaka& Nakajima, Minako& Qiao, Jing…[et al.]. Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1116266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116266