Effect of Periodic Granulocyte Colony-Stimulating Factor Administration on Endothelial Progenitor Cells and Different Monocyte Subsets in Pediatric Patients with Muscular Dystrophies
Joint Authors
Eljaszewicz, Andrzej
Grubczak, Kamil
Sienkiewicz, Dorota
Okurowska-Zawada, Bożena
Paszko-Patej, Grażyna
Miklasz, Paula
Singh, Paulina
Radzikowska, Urszula
Kulak, Wojciech
Moniuszko, Marcin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-06
Country of Publication
Egypt
No. of Pages
9
Abstract EN
Muscular dystrophies (MD) are heterogeneous group of diseases characterized by progressive muscle dysfunction.
There is a large body of evidence indicating that angiogenesis is impaired in muscles of MD patients.
Therefore, induction of dystrophic muscle revascularization should become a novel approach aimed at diminishing the extent of myocyte damage.
Recently, we and others demonstrated that administration of granulocyte colony-stimulating factor (G-CSF) resulted in clinical improvement of patients with neuromuscular disorders.
To date, however, the exact mechanisms underlying these beneficial effects of G-CSF have not been fully understood.
Here we used flow cytometry to quantitate numbers of CD34+ cells, endothelial progenitor cells, and different monocyte subsets in peripheral blood of pediatric MD patients treated with repetitive courses of G-CSF administration.
We showed that repetitive cycles of G-CSF administration induced efficient mobilization of above-mentioned cells including cells with proangiogenic potential.
These findings contribute to better understanding the beneficial clinical effects of G-CSF in pediatric MD patients.
American Psychological Association (APA)
Eljaszewicz, Andrzej& Sienkiewicz, Dorota& Grubczak, Kamil& Okurowska-Zawada, Bożena& Paszko-Patej, Grażyna& Miklasz, Paula…[et al.]. 2015. Effect of Periodic Granulocyte Colony-Stimulating Factor Administration on Endothelial Progenitor Cells and Different Monocyte Subsets in Pediatric Patients with Muscular Dystrophies. Stem Cells International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1116280
Modern Language Association (MLA)
Eljaszewicz, Andrzej…[et al.]. Effect of Periodic Granulocyte Colony-Stimulating Factor Administration on Endothelial Progenitor Cells and Different Monocyte Subsets in Pediatric Patients with Muscular Dystrophies. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1116280
American Medical Association (AMA)
Eljaszewicz, Andrzej& Sienkiewicz, Dorota& Grubczak, Kamil& Okurowska-Zawada, Bożena& Paszko-Patej, Grażyna& Miklasz, Paula…[et al.]. Effect of Periodic Granulocyte Colony-Stimulating Factor Administration on Endothelial Progenitor Cells and Different Monocyte Subsets in Pediatric Patients with Muscular Dystrophies. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1116280
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116280