Noncoding RNAs in Tumor Epithelial-to-Mesenchymal Transition
Joint Authors
Lin, Ching-Wen
Lin, Pei-Ying
Yang, Pan-Chyr
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-16
Country of Publication
Egypt
No. of Pages
13
Abstract EN
Epithelial-derived tumor cells acquire the capacity for epithelial-to-mesenchymal transition (EMT), which enables them to invade adjacent tissues and/or metastasize to distant organs.
Cancer metastasis is the main cause of cancer-related death.
Molecular mechanisms involved in the switch from an epithelial phenotype to mesenchymal status are complicated and are controlled by a variety of signaling pathways.
Recently, a set of noncoding RNAs (ncRNAs), including miRNAs and long noncoding RNAs (lncRNAs), were found to modulate gene expressions at either transcriptional or posttranscriptional levels.
These ncRNAs are involved in EMT through their interplay with EMT-related transcription factors (EMT-TFs) and EMT-associated signaling.
Reciprocal regulatory interactions between lncRNAs and miRNAs further increase the complexity of the regulation of gene expression and protein translation.
In this review, we discuss recent findings regarding EMT-regulating ncRNAs and their associated signaling pathways involved in cancer progression.
American Psychological Association (APA)
Lin, Ching-Wen& Lin, Pei-Ying& Yang, Pan-Chyr. 2016. Noncoding RNAs in Tumor Epithelial-to-Mesenchymal Transition. Stem Cells International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116300
Modern Language Association (MLA)
Lin, Ching-Wen…[et al.]. Noncoding RNAs in Tumor Epithelial-to-Mesenchymal Transition. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1116300
American Medical Association (AMA)
Lin, Ching-Wen& Lin, Pei-Ying& Yang, Pan-Chyr. Noncoding RNAs in Tumor Epithelial-to-Mesenchymal Transition. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116300