Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis

Joint Authors

Amicone, Laura
Cicchini, Carla
Strippoli, Raffaele
Moreno-Vicente, Roberto
Battistelli, Cecilia
Noce, Valeria
Marchetti, Alessandra
del Pozo, Miguel Angel
Tripodi, Marco

Source

Stem Cells International

Issue

Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-01-31

Country of Publication

Egypt

No. of Pages

11

Abstract EN

Peritoneal dialysis is a form of renal replacement alternative to the hemodialysis.

During this treatment, the peritoneal membrane acts as a permeable barrier for exchange of solutes and water.

Continual exposure to dialysis solutions, as well as episodes of peritonitis and hemoperitoneum, can cause acute/chronic inflammation and injury to the peritoneal membrane, which undergoes progressive fibrosis, angiogenesis, and vasculopathy, eventually leading to discontinuation of the peritoneal dialysis.

Among the different events controlling this pathological process, epithelial to mesenchymal transition of mesothelial cells plays a main role in the induction of fibrosis and in subsequent functional deterioration of the peritoneal membrane.

Here, the main extracellular inducers and cellular players are described.

Moreover, signaling pathways acting during this process are elucidated, with emphasis on signals delivered by TGF-β family members and by Toll-like/IL-1β receptors.

The understanding of molecular mechanisms underlying fibrosis of the peritoneal membrane has both a basic and a translational relevance, since it may be useful for setup of therapies aimed at counteracting the deterioration as well as restoring the homeostasis of the peritoneal membrane.

American Psychological Association (APA)

Strippoli, Raffaele& Moreno-Vicente, Roberto& Battistelli, Cecilia& Cicchini, Carla& Noce, Valeria& Amicone, Laura…[et al.]. 2016. Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis. Stem Cells International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116392

Modern Language Association (MLA)

Strippoli, Raffaele…[et al.]. Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1116392

American Medical Association (AMA)

Strippoli, Raffaele& Moreno-Vicente, Roberto& Battistelli, Cecilia& Cicchini, Carla& Noce, Valeria& Amicone, Laura…[et al.]. Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116392

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1116392