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StemProgenitor Cell Niches Involved in Hepatic and Biliary Regeneration
Joint Authors
Renzi, Anastasia
Franchitto, Antonio
Onori, Paolo
Reid, Lola McAdams
Alvaro, Domenico
Cardinale, Vincenzo
Gaudio, Eugenio
Carpino, Guido
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-10
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Niches containing stem/progenitor cells are present in different anatomical locations along the human biliary tree and within liver acini.
The most primitive stem/progenitors, biliary tree stem/progenitor cells (BTSCs), reside within peribiliary glands located throughout large extrahepatic and intrahepatic bile ducts.
BTSCs are multipotent and can differentiate towards hepatic and pancreatic cell fates.
These niches’ matrix chemistry and other characteristics are undefined.
Canals of Hering (bile ductules) are found periportally and contain hepatic stem/progenitor cells (HpSCs), participating in the renewal of small intrahepatic bile ducts and being precursors to hepatocytes and cholangiocytes.
The niches also contain precursors to hepatic stellate cells and endothelia, macrophages, and have a matrix chemistry rich in hyaluronans, minimally sulfated proteoglycans, fetal collagens, and laminin.
The microenvironment furnishes key signals driving HpSC activation and differentiation.
Newly discovered third niches are pericentral within hepatic acini, contain Axin2+ unipotent hepatocytic progenitors linked on their lateral borders to endothelia forming the central vein, and contribute to normal turnover of mature hepatocytes.
Their relationship to the other stem/progenitors is undefined.
Stem/progenitor niches have important implications in regenerative medicine for the liver and biliary tree and in pathogenic processes leading to diseases of these tissues.
American Psychological Association (APA)
Carpino, Guido& Renzi, Anastasia& Franchitto, Antonio& Cardinale, Vincenzo& Onori, Paolo& Reid, Lola McAdams…[et al.]. 2016. StemProgenitor Cell Niches Involved in Hepatic and Biliary Regeneration. Stem Cells International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1116414
Modern Language Association (MLA)
Carpino, Guido…[et al.]. StemProgenitor Cell Niches Involved in Hepatic and Biliary Regeneration. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1116414
American Medical Association (AMA)
Carpino, Guido& Renzi, Anastasia& Franchitto, Antonio& Cardinale, Vincenzo& Onori, Paolo& Reid, Lola McAdams…[et al.]. StemProgenitor Cell Niches Involved in Hepatic and Biliary Regeneration. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1116414
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116414