![](/images/graphics-bg.png)
Cancer Stem Cell Plasticity as Tumor Growth Promoter and Catalyst of Population Collapse
Joint Authors
Enderling, Heiko
Poleszczuk, Jan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-08
Country of Publication
Egypt
No. of Pages
12
Abstract EN
It is increasingly argued that cancer stem cells are not a cellular phenotype but rather a transient state that cells can acquire, either through intrinsic signaling cascades or in response to environmental cues.
While cancer stem cell plasticity is generally associated with increased aggressiveness and treatment resistance, we set out to thoroughly investigate the impact of different rates of plasticity on early and late tumor growth dynamics and the response to therapy.
We develop an agent-based model of cancer stem cell driven tumor growth, in which plasticity is defined as a spontaneous transition between stem and nonstem cancer cell states.
Simulations of the model show that plasticity can substantially increase tumor growth rate and invasion.
At high rates of plasticity, however, the cells get exhausted and the tumor will undergo spontaneous remission in the long term.
In a series of in silico trials, we show that such remission can be facilitated through radiotherapy.
The presented study suggests that stem cell plasticity has rather complex, nonintuitive implications on tumor growth and treatment response.
Further theoretical, experimental, and integrated studies are needed to fully decipher cancer stem cell plasticity and how it can be harnessed for novel therapeutic approaches.
American Psychological Association (APA)
Poleszczuk, Jan& Enderling, Heiko. 2015. Cancer Stem Cell Plasticity as Tumor Growth Promoter and Catalyst of Population Collapse. Stem Cells International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1116460
Modern Language Association (MLA)
Poleszczuk, Jan& Enderling, Heiko. Cancer Stem Cell Plasticity as Tumor Growth Promoter and Catalyst of Population Collapse. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1116460
American Medical Association (AMA)
Poleszczuk, Jan& Enderling, Heiko. Cancer Stem Cell Plasticity as Tumor Growth Promoter and Catalyst of Population Collapse. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1116460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116460