MicroRNAs: From Female Fertility, Germ Cells, and Stem Cells to Cancer in Humans
Joint Authors
Ståhlberg, Anders
Skutella, Thomas
Virant-Klun, Irma
Kubista, Mikael
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-09
Country of Publication
Egypt
No. of Pages
17
Abstract EN
MicroRNAs are a family of naturally occurring small noncoding RNA molecules that play an important regulatory role in gene expression.
They are suggested to regulate a large proportion of protein encoding genes by mediating the translational suppression and posttranscriptional control of gene expression.
Recent findings show that microRNAs are emerging as important regulators of cellular differentiation and dedifferentiation, and are deeply involved in developmental processes including human preimplantation development.
They keep a balance between pluripotency and differentiation in the embryo and embryonic stem cells.
Moreover, it became evident that dysregulation of microRNA expression may play a fundamental role in progression and dissemination of different cancers including ovarian cancer.
The interest is still increased by the discovery of exosomes, that is, cell-derived vesicles, which can carry different proteins but also microRNAs between different cells and are involved in cell-to-cell communication.
MicroRNAs, together with exosomes, have a great potential to be used for prognosis, therapy, and biomarkers of different diseases including infertility.
The aim of this review paper is to summarize the existent knowledge on microRNAs related to female fertility and cancer: from primordial germ cells and ovarian function, germinal stem cells, oocytes, and embryos to embryonic stem cells.
American Psychological Association (APA)
Virant-Klun, Irma& Ståhlberg, Anders& Kubista, Mikael& Skutella, Thomas. 2015. MicroRNAs: From Female Fertility, Germ Cells, and Stem Cells to Cancer in Humans. Stem Cells International،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1116470
Modern Language Association (MLA)
Virant-Klun, Irma…[et al.]. MicroRNAs: From Female Fertility, Germ Cells, and Stem Cells to Cancer in Humans. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1116470
American Medical Association (AMA)
Virant-Klun, Irma& Ståhlberg, Anders& Kubista, Mikael& Skutella, Thomas. MicroRNAs: From Female Fertility, Germ Cells, and Stem Cells to Cancer in Humans. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1116470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116470