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Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria
Joint Authors
Wang, Dandan
Geng, Linyu
Chen, Jinyun
Wang, Qian
Zhang, Zhuoya
Xu, Ting
Feng, Xuebing
Sun, Ling-Yun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-07
Country of Publication
Egypt
No. of Pages
13
Abstract EN
Aberrant autophagy played an important role in the pathogenesis of autoimmune diseases, especially in systemic lupus erythematosus (SLE).
In this study, we showed that T cells from SLE patients had higher autophagic activity than that from healthy controls.
A correlation between autophagic activity and apoptotic rate was observed in activated T cells.
Moreover, activation of autophagy with rapamycin increased T cell apoptosis, whereas inhibition of autophagy with 3-MA decreased T cell apoptosis.
Umbilical cord-derived mesenchymal stem cells (UC-MSCs) could inhibit respiratory mitochondrial biogenesis in activated T cells to downregulate autophagy and consequently decrease T cell apoptosis through mitochondrial transfer and thus may play an important role in SLE treatment.
American Psychological Association (APA)
Chen, Jinyun& Wang, Qian& Feng, Xuebing& Zhang, Zhuoya& Geng, Linyu& Xu, Ting…[et al.]. 2016. Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria. Stem Cells International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116485
Modern Language Association (MLA)
Chen, Jinyun…[et al.]. Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1116485
American Medical Association (AMA)
Chen, Jinyun& Wang, Qian& Feng, Xuebing& Zhang, Zhuoya& Geng, Linyu& Xu, Ting…[et al.]. Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116485
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116485