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Stem Cell Mobilization with G-CSF versus Cyclophosphamide plus G-CSF in Mexican Children
Joint Authors
Jiménez-Hernández, Elva
Arellano-Galindo, José
Vázquez Meraz, José Eugenio
Martínez Avalos, Armando
Mendoza-García, Emma
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
4
Abstract EN
Fifty-six aphaereses were performed in 23 pediatric patients with malignant hematological and solid tumors, following three different protocols for PBPC mobilization and distributed as follows: A: seventeen mobilized with 4 g/m2 of cyclophosphamide (CFA) and 10 μg/kg/day of granulocyte colony stimulating factor (G-CSF), B: nineteen with CFA + G-CSF, and C: twenty only with G-CSF when the WBC count exceeded 10 × 109/L.
The average number of MNC/kg body weight (BW)/aphaeresis was 0.4 × 108 (0.1–1.4), 2.25 × 108 (0.56–6.28), and 1.02 × 108 (0.34–2.5) whereas the average number of CD34+ cells/kg BW/aphaeresis was 0.18 × 106/kg (0.09–0.34), 1.04 × 106 (0.19–9.3), and 0.59 × 106 (0.17–0.87) and the count of CFU/kg BW/aphaeresis was 1.11 × 105 (0.31–2.12), 1.16 × 105 (0.64–2.97), and 1.12 × 105 (0.3–6.63) in groups A, B, and C, respectively.
The collection was better in group B versus group A ( p = 0.007 and p = 0.05 , resp.) and in group C versus group A ( p = 0.08 and p = 0.05 , resp.).
The collection of PBPCs was more effective in the group mobilized with CFM + G-CSF when the WBC exceeded 10 × 103/μL in terms of MNC and CD34+ cells and there was no toxicity of the chemotherapy.
American Psychological Association (APA)
Vázquez Meraz, José Eugenio& Arellano-Galindo, José& Martínez Avalos, Armando& Mendoza-García, Emma& Jiménez-Hernández, Elva. 2016. Stem Cell Mobilization with G-CSF versus Cyclophosphamide plus G-CSF in Mexican Children. Stem Cells International،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1116493
Modern Language Association (MLA)
Vázquez Meraz, José Eugenio…[et al.]. Stem Cell Mobilization with G-CSF versus Cyclophosphamide plus G-CSF in Mexican Children. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-4.
https://search.emarefa.net/detail/BIM-1116493
American Medical Association (AMA)
Vázquez Meraz, José Eugenio& Arellano-Galindo, José& Martínez Avalos, Armando& Mendoza-García, Emma& Jiménez-Hernández, Elva. Stem Cell Mobilization with G-CSF versus Cyclophosphamide plus G-CSF in Mexican Children. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1116493
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116493