Stem Cells of Dental Origin: Current Research Trends and Key Milestones towards Clinical Application
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-13
Country of Publication
Egypt
No. of Pages
20
Abstract EN
Dental Mesenchymal Stem Cells (MSCs), including Dental Pulp Stem Cells (DPSCs), Stem Cells from Human Exfoliated Deciduous teeth (SHED), and Stem Cells From Apical Papilla (SCAP), have been extensively studied using highly sophisticated in vitro and in vivo systems, yielding substantially improved understanding of their intriguing biological properties.
Their capacity to reconstitute various dental and nondental tissues and the inherent angiogenic, neurogenic, and immunomodulatory properties of their secretome have been a subject of meticulous and costly research by various groups over the past decade.
Key milestone achievements have exemplified their clinical utility in Regenerative Dentistry, as surrogate therapeutic modules for conventional biomaterial-based approaches, offering regeneration of damaged oral tissues instead of simply “filling the gaps.” Thus, the essential next step to validate these immense advances is the implementation of well-designed clinical trials paving the way for exploiting these fascinating research achievements for patient well-being: the ultimate aim of this ground breaking technology.
This review paper presents a concise overview of the major biological properties of the human dental MSCs, critical for the translational pathway “from bench to clinic.”
American Psychological Association (APA)
Bakopoulou, Athina& About, Imad. 2016. Stem Cells of Dental Origin: Current Research Trends and Key Milestones towards Clinical Application. Stem Cells International،Vol. 2016, no. 2016, pp.1-20.
https://search.emarefa.net/detail/BIM-1116525
Modern Language Association (MLA)
Bakopoulou, Athina& About, Imad. Stem Cells of Dental Origin: Current Research Trends and Key Milestones towards Clinical Application. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-20.
https://search.emarefa.net/detail/BIM-1116525
American Medical Association (AMA)
Bakopoulou, Athina& About, Imad. Stem Cells of Dental Origin: Current Research Trends and Key Milestones towards Clinical Application. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-20.
https://search.emarefa.net/detail/BIM-1116525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116525