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Review of Preclinical and Clinical Studies of Bone Marrow-Derived Cell Therapies for Intracerebral Hemorrhage
Joint Authors
Pimentel-Coelho, Pedro Moreno
de Carvalho, Felipe Gonçalves
de Freitas, Gabriel Rodriguez
Rosado-de-Castro, Paulo Henrique
Mendez-Otero, Rosalia
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-06
Country of Publication
Egypt
No. of Pages
18
Abstract EN
Stroke is the second leading cause of mortality worldwide, causing millions of deaths annually, and is also a major cause of disability-adjusted life years.
Hemorrhagic stroke accounts for approximately 10 to 27% of all cases and has a fatality rate of about 50% in the first 30 days, with limited treatment possibilities.
In the past two decades, the therapeutic potential of bone marrow-derived cells (particularly mesenchymal stem cells and mononuclear cells) has been intensively investigated in preclinical models of different neurological diseases, including models of intracerebral hemorrhage and subarachnoid hemorrhage.
More recently, clinical studies, most of them small, unblinded, and nonrandomized, have suggested that the therapy with bone marrow-derived cells is safe and feasible in patients with ischemic or hemorrhagic stroke.
This review discusses the available evidence on the use of bone marrow-derived cells to treat hemorrhagic strokes.
Distinctive properties of animal studies are analyzed, including study design, cell dose, administration route, therapeutic time window, and possible mechanisms of action.
Furthermore, clinical trials are also reviewed and discussed, with the objective of improving future studies in the field.
American Psychological Association (APA)
Rosado-de-Castro, Paulo Henrique& de Carvalho, Felipe Gonçalves& de Freitas, Gabriel Rodriguez& Mendez-Otero, Rosalia& Pimentel-Coelho, Pedro Moreno. 2016. Review of Preclinical and Clinical Studies of Bone Marrow-Derived Cell Therapies for Intracerebral Hemorrhage. Stem Cells International،Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1116590
Modern Language Association (MLA)
Rosado-de-Castro, Paulo Henrique…[et al.]. Review of Preclinical and Clinical Studies of Bone Marrow-Derived Cell Therapies for Intracerebral Hemorrhage. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-18.
https://search.emarefa.net/detail/BIM-1116590
American Medical Association (AMA)
Rosado-de-Castro, Paulo Henrique& de Carvalho, Felipe Gonçalves& de Freitas, Gabriel Rodriguez& Mendez-Otero, Rosalia& Pimentel-Coelho, Pedro Moreno. Review of Preclinical and Clinical Studies of Bone Marrow-Derived Cell Therapies for Intracerebral Hemorrhage. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1116590
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116590