Vascular Remodelling and Mesenchymal Transition in Systemic Sclerosis
Joint Authors
Brunelli, Silvia
Rovere-Querini, Patrizia
Manfredi, Angelo A.
Nicolosi, Pier Andrea
Tombetti, Enrico
Maugeri, Norma
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-16
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Fibrosis of the skin and of internal organs, autoimmunity, and vascular inflammation are hallmarks of Systemic Sclerosis (SSc).
The injury and activation of endothelial cells, with hyperplasia of the intima and eventual obliteration of the vascular lumen, are early features of SSc.
Reduced capillary blood flow coupled with deficient angiogenesis leads to chronic hypoxia and tissue ischemia, enforcing a positive feed-forward loop sustaining vascular remodelling, further exacerbated by extracellular matrix accumulation due to fibrosis.
Despite numerous developments and a growing number of controlled clinical trials no treatment has been shown so far to alter SSc natural history, outlining the need of further investigation in the molecular pathways involved in the pathogenesis of the disease.
We review some processes potentially involved in SSc vasculopathy, with attention to the possible effect of sustained vascular inflammation on the plasticity of vascular cells.
Specifically we focus on mesenchymal transition, a key phenomenon in the cardiac and vascular development as well as in the remodelling of injured vessels.
Recent work supports the role of transforming growth factor-beta, Wnt, and Notch signaling in these processes.
Importantly, endothelial-mesenchymal transition may be reversible, possibly offering novel cues for treatment.
American Psychological Association (APA)
Nicolosi, Pier Andrea& Tombetti, Enrico& Maugeri, Norma& Rovere-Querini, Patrizia& Brunelli, Silvia& Manfredi, Angelo A.. 2016. Vascular Remodelling and Mesenchymal Transition in Systemic Sclerosis. Stem Cells International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1116602
Modern Language Association (MLA)
Nicolosi, Pier Andrea…[et al.]. Vascular Remodelling and Mesenchymal Transition in Systemic Sclerosis. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1116602
American Medical Association (AMA)
Nicolosi, Pier Andrea& Tombetti, Enrico& Maugeri, Norma& Rovere-Querini, Patrizia& Brunelli, Silvia& Manfredi, Angelo A.. Vascular Remodelling and Mesenchymal Transition in Systemic Sclerosis. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1116602
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116602