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Mesenchymal Stem Cell-Based Therapy for Kidney Disease: A Review of Clinical Evidence
Joint Authors
Peired, Anna Julie
Sisti, Alessandro
Romagnani, Paola
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-19
Country of Publication
Egypt
No. of Pages
22
Abstract EN
Mesenchymal stem cells form a population of self-renewing, multipotent cells that can be isolated from several tissues.
Multiple preclinical studies have demonstrated that the administration of exogenous MSC could prevent renal injury and could promote renal recovery through a series of complex mechanisms, in particular via immunomodulation of the immune system and release of paracrine factors and microvesicles.
Due to their therapeutic potentials, MSC are being evaluated as a possible player in treatment of human kidney disease, and an increasing number of clinical trials to assess the safety, feasibility, and efficacy of MSC-based therapy in various kidney diseases have been proposed.
In the present review, we will summarize the current knowledge on MSC infusion to treat acute kidney injury, chronic kidney disease, diabetic nephropathy, focal segmental glomerulosclerosis, systemic lupus erythematosus, and kidney transplantation.
The data obtained from these clinical trials will provide further insight into safety, feasibility, and efficacy of MSC-based therapy in renal pathologies and allow the design of consensus protocol for clinical purpose.
American Psychological Association (APA)
Peired, Anna Julie& Sisti, Alessandro& Romagnani, Paola. 2016. Mesenchymal Stem Cell-Based Therapy for Kidney Disease: A Review of Clinical Evidence. Stem Cells International،Vol. 2016, no. 2016, pp.1-22.
https://search.emarefa.net/detail/BIM-1116639
Modern Language Association (MLA)
Peired, Anna Julie…[et al.]. Mesenchymal Stem Cell-Based Therapy for Kidney Disease: A Review of Clinical Evidence. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-22.
https://search.emarefa.net/detail/BIM-1116639
American Medical Association (AMA)
Peired, Anna Julie& Sisti, Alessandro& Romagnani, Paola. Mesenchymal Stem Cell-Based Therapy for Kidney Disease: A Review of Clinical Evidence. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-22.
https://search.emarefa.net/detail/BIM-1116639
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116639