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Tumor Budding, Micropapillary Pattern, and Polyploidy Giant Cancer Cells in Colorectal Cancer: Current Status and Future Prospects
Joint Authors
Yang, Zhengduo
Zhang, Xipeng
Zhang, Dan
Zhang, Shiwu
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-23
Country of Publication
Egypt
No. of Pages
8
Abstract EN
We previously reported that polyploid giant cancer cells (PGCGs) induced by CoCl2 could form through endoreduplication or cell fusion.
A single PGCC formed tumors in immunodeficient mice.
PGCCs are also the key contributors to the cellular atypia and associate with the malignant grade of tumors.
PGCCs have the properties of cancer stem cells and produce daughter cells via asymmetric cell division.
Compared with diploid cancer cells, these daughter cells express less epithelial markers and acquire mesenchymal phenotype with importance in cancer development and progression.
Tumor budding is generally recognized to correlate with a high recurrence rate, lymph node metastasis, chemoresistance, and poor prognosis of colorectal cancers (CRCs) and is a good indicator to predict the metastasis and aggressiveness in CRCs.
Micropapillary pattern is a special morphologic pattern and also associates with tumor metastasis and poor prognosis.
There are similar morphologic features and molecular phenotypes among tumor budding, micropapillary carcinoma pattern, and PGCCs with their budding daughter cells and all of them show strong ability of tumor invasion and migration.
In this review, we discuss the cancer stem cell properties of PGCCs, the molecular mechanisms of their regulation, and the relationships with tumor budding and micropapillary pattern in CRCs.
American Psychological Association (APA)
Zhang, Shiwu& Zhang, Dan& Yang, Zhengduo& Zhang, Xipeng. 2016. Tumor Budding, Micropapillary Pattern, and Polyploidy Giant Cancer Cells in Colorectal Cancer: Current Status and Future Prospects. Stem Cells International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116642
Modern Language Association (MLA)
Zhang, Shiwu…[et al.]. Tumor Budding, Micropapillary Pattern, and Polyploidy Giant Cancer Cells in Colorectal Cancer: Current Status and Future Prospects. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1116642
American Medical Association (AMA)
Zhang, Shiwu& Zhang, Dan& Yang, Zhengduo& Zhang, Xipeng. Tumor Budding, Micropapillary Pattern, and Polyploidy Giant Cancer Cells in Colorectal Cancer: Current Status and Future Prospects. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116642