The Effect of MSCs Derived from the Human Umbilical Cord Transduced by Fibroblast Growth Factor-20 on Parkinson’s Disease
Joint Authors
Li, Jin-Feng
Duan, Hai-Feng
Liu, Xin-Shan
Wang, Shan-Shan
Yin, Hong-Lei
Peng, Xue
Xiaopeng, Yang
Bingzhen, Cao
Chunyang, Xu
Zhixiu, Xu
Xia, Cao
Wang, Yunliang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-05
Country of Publication
Egypt
No. of Pages
9
Abstract EN
Cell therapy is a potential therapeutic approach for Parkinson’s disease (PD).
Mesenchymal stem cells derived from the human umbilical cord (hUC-MSCs) give priority to PD patients because of multiple advantages.
The appropriate gene transduction of hUC-MSC before transplantation is a promising procedure for cell therapy.
Fibroblast growth factor-20 (FGF-20) has been shown to protect dopaminergic neurons against a range of toxic insults in vitro.
In this study, the hUC-MSCs were gene transduced with FGF-20, and then we transplanted them into the PD mice model.
The results showed that MSC-FGF-20 treatment obviously improved the behavior of PD, accompanied by the increase of tyrosine carboxylase- (TH-) positive cell and dopamine (DA).
Furtherly, immunohistochemistry disclosed that MSC-FGF-20 obviously promoted the degradation of nuclear factor-κB (NF-κB), a transcription factor that controls genes encoding proinflammatory cytokines, highly expressed in the nigrostriatal dopaminergic regions in PD patients.
Therefore, MSC-FGF-20 has a potential for improving PD, closely related to the degradation of NF-κB.
American Psychological Association (APA)
Li, Jin-Feng& Wang, Yunliang& Liu, Xin-Shan& Wang, Shan-Shan& Chunyang, Xu& Peng, Xue…[et al.]. 2016. The Effect of MSCs Derived from the Human Umbilical Cord Transduced by Fibroblast Growth Factor-20 on Parkinson’s Disease. Stem Cells International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1116681
Modern Language Association (MLA)
Li, Jin-Feng…[et al.]. The Effect of MSCs Derived from the Human Umbilical Cord Transduced by Fibroblast Growth Factor-20 on Parkinson’s Disease. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1116681
American Medical Association (AMA)
Li, Jin-Feng& Wang, Yunliang& Liu, Xin-Shan& Wang, Shan-Shan& Chunyang, Xu& Peng, Xue…[et al.]. The Effect of MSCs Derived from the Human Umbilical Cord Transduced by Fibroblast Growth Factor-20 on Parkinson’s Disease. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1116681
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116681