Bone Marrow-Derived Cells as a Therapeutic Approach to Optic Nerve Diseases
Joint Authors
Pimentel-Coelho, Pedro Moreno
Mesentier-Louro, Louise A.
Zaverucha-do-Valle, Camila
Silva-Junior, Almir J.
Santiago, Marcelo F.
Rosado-de-Castro, Paulo Henrique
Mendez-Otero, Rosalia
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-16
Country of Publication
Egypt
No. of Pages
16
Abstract EN
Following optic nerve injury associated with acute or progressive diseases, retinal ganglion cells (RGCs) of adult mammals degenerate and undergo apoptosis.
These diseases have limited therapeutic options, due to the low inherent capacity of RGCs to regenerate and due to the inhibitory milieu of the central nervous system.
Among the numerous treatment approaches investigated to stimulate neuronal survival and axonal extension, cell transplantation emerges as a promising option.
This review focuses on cell therapies with bone marrow mononuclear cells and bone marrow-derived mesenchymal stem cells, which have shown positive therapeutic effects in animal models of optic neuropathies.
Different aspects of available preclinical studies are analyzed, including cell distribution, potential doses, routes of administration, and mechanisms of action.
Finally, published and ongoing clinical trials are summarized.
American Psychological Association (APA)
Mesentier-Louro, Louise A.& Zaverucha-do-Valle, Camila& Rosado-de-Castro, Paulo Henrique& Silva-Junior, Almir J.& Pimentel-Coelho, Pedro Moreno& Mendez-Otero, Rosalia…[et al.]. 2015. Bone Marrow-Derived Cells as a Therapeutic Approach to Optic Nerve Diseases. Stem Cells International،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1116688
Modern Language Association (MLA)
Mesentier-Louro, Louise A.…[et al.]. Bone Marrow-Derived Cells as a Therapeutic Approach to Optic Nerve Diseases. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1116688
American Medical Association (AMA)
Mesentier-Louro, Louise A.& Zaverucha-do-Valle, Camila& Rosado-de-Castro, Paulo Henrique& Silva-Junior, Almir J.& Pimentel-Coelho, Pedro Moreno& Mendez-Otero, Rosalia…[et al.]. Bone Marrow-Derived Cells as a Therapeutic Approach to Optic Nerve Diseases. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1116688
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116688