Genetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell Function
Joint Authors
Kosan, Christian
Godmann, Maren
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-20
Country of Publication
Egypt
No. of Pages
14
Abstract EN
All hematopoiesis cells develop from multipotent progenitor cells.
Hematopoietic stem cells (HSC) have the ability to develop into all blood lineages but also maintain their stemness.
Different molecular mechanisms have been identified that are crucial for regulating quiescence and self-renewal to maintain the stem cell pool and for inducing proliferation and lineage differentiation.
The stem cell niche provides the microenvironment to keep HSC in a quiescent state.
Furthermore, several transcription factors and epigenetic modifiers are involved in this process.
These create modifications that regulate the cell fate in a more or less reversible and dynamic way and contribute to HSC homeostasis.
In addition, HSC respond in a unique way to DNA damage.
These mechanisms also contribute to the regulation of HSC function and are essential to ensure viability after DNA damage.
How HSC maintain their quiescent stage during the entire life is still matter of ongoing research.
Here we will focus on the molecular mechanisms that regulate HSC function.
American Psychological Association (APA)
Kosan, Christian& Godmann, Maren. 2015. Genetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell Function. Stem Cells International،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1116715
Modern Language Association (MLA)
Kosan, Christian& Godmann, Maren. Genetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell Function. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1116715
American Medical Association (AMA)
Kosan, Christian& Godmann, Maren. Genetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell Function. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1116715
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116715