Potential Role of Activating Transcription Factor 5 during Osteogenesis
Joint Authors
Vicari, Luisa
Calabrese, Giovanna
Forte, Stefano
Giuffrida, Raffaella
Colarossi, Cristina
Memeo, Lorenzo
Parrinello, Nunziatina Laura
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-06
Country of Publication
Egypt
No. of Pages
8
Abstract EN
Human adipose-derived stem cells are an abundant population of stem cells readily isolated from human adipose tissue that can differentiate into connective tissue lineages including bone, cartilage, fat, and muscle.
Activating transcription factor 5 is a transcription factor of the ATF/cAMP response element-binding protein (CREB) family.
It is transcribed in two types of mRNAs (activating transcription factor 5 isoform 1 and activating transcription factor 5 isoform 2), encoding the same single 30-kDa protein.
Although it is well demonstrated that it regulates the proliferation, differentiation, and apoptosis, little is known about its potential role in osteogenic differentiation.
The aim of this study was to evaluate the expression levels of the two isoforms and protein during osteogenic differentiation of human adipose-derived stem cells.
Our data indicate that activating transcription factor 5 is differentially expressed reaching a peak of expression at the stage of bone mineralization.
These findings suggest that activating transcription factor 5 could play an interesting regulatory role during osteogenesis, which would provide a powerful tool to study bone physiology.
American Psychological Association (APA)
Vicari, Luisa& Calabrese, Giovanna& Forte, Stefano& Giuffrida, Raffaella& Colarossi, Cristina& Parrinello, Nunziatina Laura…[et al.]. 2015. Potential Role of Activating Transcription Factor 5 during Osteogenesis. Stem Cells International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116728
Modern Language Association (MLA)
Vicari, Luisa…[et al.]. Potential Role of Activating Transcription Factor 5 during Osteogenesis. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1116728
American Medical Association (AMA)
Vicari, Luisa& Calabrese, Giovanna& Forte, Stefano& Giuffrida, Raffaella& Colarossi, Cristina& Parrinello, Nunziatina Laura…[et al.]. Potential Role of Activating Transcription Factor 5 during Osteogenesis. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116728
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116728