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Tackling Cancer Stem Cells via Inhibition of EMT Transcription Factors
Joint Authors
Mladinich, Megan
Ruan, Diane
Chan, Chia-Hsin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-20
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Cancer stem cell (CSC) has become recognized for its role in both tumorigenesis and poor patient prognosis in recent years.
Traditional therapeutics are unable to effectively eliminate this group of cells from the bulk population of cancer cells, allowing CSCs to persist posttreatment and thus propagate into secondary tumors.
The therapeutic potential of eliminating CSCs, to decrease tumor relapse, has created a demand for identifying mechanisms that directly target and eliminate cancer stem cells.
Molecular profiling has shown that cancer cells and tumors that exhibit the CSC phenotype also express genes associated with the epithelial-to-mesenchymal transition (EMT) feature.
Ample evidence has demonstrated that upregulation of master transcription factors (TFs) accounting for the EMT process such as Snail/Slug and Twist can reprogram cancer cells from differentiated to stem-like status.
Despite being appealing therapeutic targets for tackling CSCs, pharmacological approaches that directly target EMT-TFs remain impossible.
In this review, we will summarize recent advances in the regulation of Snail/Slug and Twist at transcriptional, translational, and posttranslational levels and discuss the clinical implication and application for EMT blockade as a promising strategy for CSC targeting.
American Psychological Association (APA)
Mladinich, Megan& Ruan, Diane& Chan, Chia-Hsin. 2016. Tackling Cancer Stem Cells via Inhibition of EMT Transcription Factors. Stem Cells International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1116731
Modern Language Association (MLA)
Mladinich, Megan…[et al.]. Tackling Cancer Stem Cells via Inhibition of EMT Transcription Factors. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1116731
American Medical Association (AMA)
Mladinich, Megan& Ruan, Diane& Chan, Chia-Hsin. Tackling Cancer Stem Cells via Inhibition of EMT Transcription Factors. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1116731
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116731