Antimicrobial Properties of Mesenchymal Stem Cells: Therapeutic Potential for Cystic Fibrosis Infection, and Treatment
Joint Authors
Reese, Jane S.
Sutton, Morgan T.
Caplan, Arnold I.
Fletcher, David
Ghosh, Santosh K.
Weinberg, Aaron
van Heeckeren, Rolf
Kaur, Sukhmani
Sadeghi, Zhina
Hijaz, Adonis
Lazarus, Hillard M.
Lennon, Donald P.
Bonfield, Tracey L.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-26
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Cystic fibrosis (CF) is a genetic disease in which the battle between pulmonary infection and inflammation becomes the major cause of morbidity and mortality.
We have previously shown that human MSCs (hMSCs) decrease inflammation and infection in the in vivo murine model of CF.
The studies in this paper focus on the specificity of the hMSC antimicrobial effectiveness using Pseudomonas aeruginosa (gram negative bacteria) and Staphylococcus aureus (gram positive bacteria).
Our studies show that hMSCs secrete bioactive molecules which are antimicrobial in vitro against Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumonia, impacting the rate of bacterial growth and transition into colony forming units regardless of the pathogen.
Further, we show that the hMSCs have the capacity to enhance antibiotic sensitivity, improving the capacity to kill bacteria.
We present data which suggests that the antimicrobial effectiveness is associated with the capacity to slow bacterial growth and the ability of the hMSCs to secrete the antimicrobial peptide LL-37.
Lastly, our studies demonstrate that the tissue origin of the hMSCs (bone marrow or adipose tissue derived), the presence of functional cystic fibrosis transmembrane conductance regulator (CFTR: human, Cftr: mouse) activity, and response to effector cytokines can impact both hMSC phenotype and antimicrobial potency and efficacy.
These studies demonstrate, the unique capacity of the hMSCs to manage different pathogens and the significance of their phenotype in both the antimicrobial and antibiotic enhancing activities.
American Psychological Association (APA)
Sutton, Morgan T.& Fletcher, David& Ghosh, Santosh K.& Weinberg, Aaron& van Heeckeren, Rolf& Kaur, Sukhmani…[et al.]. 2016. Antimicrobial Properties of Mesenchymal Stem Cells: Therapeutic Potential for Cystic Fibrosis Infection, and Treatment. Stem Cells International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1116734
Modern Language Association (MLA)
Sutton, Morgan T.…[et al.]. Antimicrobial Properties of Mesenchymal Stem Cells: Therapeutic Potential for Cystic Fibrosis Infection, and Treatment. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1116734
American Medical Association (AMA)
Sutton, Morgan T.& Fletcher, David& Ghosh, Santosh K.& Weinberg, Aaron& van Heeckeren, Rolf& Kaur, Sukhmani…[et al.]. Antimicrobial Properties of Mesenchymal Stem Cells: Therapeutic Potential for Cystic Fibrosis Infection, and Treatment. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1116734
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116734