Adipose-Derived Stem Cells Alleviate Radiation-Induced Muscular Fibrosis by Suppressing the Expression of TGF-β1
Joint Authors
Sun, Wei
Ni, Xinchu
Sun, Suping
Cai, Leiming
Yu, Jingping
Wang, Jian
Nie, Bin
Sun, Zhiqiang
Ni, Xinye
Cao, Xiufeng
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-16
Country of Publication
Egypt
No. of Pages
9
Abstract EN
We aim to investigate the effects of adipose-derived stem cells (ASCs) transplantation on irradiation-induced skeletal muscle fibrosis.
Sixty-four rabbits were randomly divided into ASCs group and PBS group followed by irradiation at unilateral hip with a single dose of 80 Gy.
Nonirradiated side with normal skeletal muscle served as normal control.
Skeletal muscle tissues were collected from eight rabbits in each group at 1 w, 4 w, 8 w, and 26 w after irradiation.
Migration of ASCs was observed in the peripheral tissues along the needle passage in the injured muscle.
The proportion of the area of collagen fibers to the total area in sections of ASCs group was lower than those of PBS groups at 4 w, 8 w, and 26 w after irradiation.
Significant decrease was noted in the integrated optimal density of the transforming growth factor β1 (TGF-β1) in the ASCs group compared with those of PBS group at 4 w, 8 w, and 26 w after irradiation.
Moreover, the expression of TGF-β1 was lower in the ASCs group compared to those of the PBS group at each time point determined by Western blot analysis.
ASCs transplantation could alleviate irradiation fibrosis by suppressing the level of TGF-β1 in the irradiated skeletal muscle.
American Psychological Association (APA)
Sun, Wei& Ni, Xinchu& Sun, Suping& Cai, Leiming& Yu, Jingping& Wang, Jian…[et al.]. 2015. Adipose-Derived Stem Cells Alleviate Radiation-Induced Muscular Fibrosis by Suppressing the Expression of TGF-β1. Stem Cells International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1116779
Modern Language Association (MLA)
Sun, Wei…[et al.]. Adipose-Derived Stem Cells Alleviate Radiation-Induced Muscular Fibrosis by Suppressing the Expression of TGF-β1. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1116779
American Medical Association (AMA)
Sun, Wei& Ni, Xinchu& Sun, Suping& Cai, Leiming& Yu, Jingping& Wang, Jian…[et al.]. Adipose-Derived Stem Cells Alleviate Radiation-Induced Muscular Fibrosis by Suppressing the Expression of TGF-β1. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1116779
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116779