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A Transcriptomic Signature of Mouse Liver Progenitor Cells
Joint Authors
Passman, Adam M.
Low, Jasmine
London, Roslyn
Tirnitz-Parker, Janina E. E.
Miyajima, Atsushi
Tanaka, Minoru
Strick-Marchand, Helene
Darlington, Gretchen J.
Finch-Edmondson, Megan
Ochsner, Scott
Zhu, Cornelia
Whelan, James
Callus, Bernard A.
Yeoh, George C. T.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-03
Country of Publication
Egypt
No. of Pages
15
Abstract EN
Liver progenitor cells (LPCs) can proliferate extensively, are able to differentiate into hepatocytes and cholangiocytes, and contribute to liver regeneration.
The presence of LPCs, however, often accompanies liver disease and hepatocellular carcinoma (HCC), indicating that they may be a cancer stem cell.
Understanding LPC biology and establishing a sensitive, rapid, and reliable method to detect their presence in the liver will assist diagnosis and facilitate monitoring of treatment outcomes in patients with liver pathologies.
A transcriptomic meta-analysis of over 400 microarrays was undertaken to compare LPC lines against datasets of muscle and embryonic stem cell lines, embryonic and developed liver (DL), and HCC.
Three gene clusters distinguishing LPCs from other liver cell types were identified.
Pathways overrepresented in these clusters denote the proliferative nature of LPCs and their association with HCC.
Our analysis also revealed 26 novel markers, LPC markers, including Mcm2 and Ltbp3, and eight known LPC markers, including M2pk and Ncam.
These markers specified the presence of LPCs in pathological liver tissue by qPCR and correlated with LPC abundance determined using immunohistochemistry.
These results showcase the value of global transcript profiling to identify pathways and markers that may be used to detect LPCs in injured or diseased liver.
American Psychological Association (APA)
Passman, Adam M.& Low, Jasmine& London, Roslyn& Tirnitz-Parker, Janina E. E.& Miyajima, Atsushi& Tanaka, Minoru…[et al.]. 2016. A Transcriptomic Signature of Mouse Liver Progenitor Cells. Stem Cells International،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1116796
Modern Language Association (MLA)
Passman, Adam M.…[et al.]. A Transcriptomic Signature of Mouse Liver Progenitor Cells. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1116796
American Medical Association (AMA)
Passman, Adam M.& Low, Jasmine& London, Roslyn& Tirnitz-Parker, Janina E. E.& Miyajima, Atsushi& Tanaka, Minoru…[et al.]. A Transcriptomic Signature of Mouse Liver Progenitor Cells. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1116796
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116796