Comparison of the Treatment Efficiency of Bone Marrow-Derived Mesenchymal Stem Cell Transplantation via Tail and Portal Veins in CCl4-Induced Mouse Liver Fibrosis

Joint Authors

Truong, Nhung Hai
Nguyen, Nam Hai
Le, Trinh Van
Vu, Ngoc Bich
Huynh, Nghia
Nguyen, Thanh Van
Le, Huy Minh
Phan, Ngoc Kim
Van Pham, Phuc

Source

Stem Cells International

Issue

Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-12-29

Country of Publication

Egypt

No. of Pages

13

Abstract EN

Because of self-renewal, strong proliferation in vitro, abundant sources for isolation, and a high differentiation capacity, mesenchymal stem cells are suggested to be potentially therapeutic for liver fibrosis/cirrhosis.

In this study, we evaluated the treatment effects of mouse bone marrow-derived mesenchymal stem cells (BM-MSCs) on mouse liver cirrhosis induced by carbon tetrachloride.

Portal and tail vein transplantations were examined to evaluate the effects of different injection routes on the liver cirrhosis model at 21 days after transplantation.

BM-MSCs transplantation reduced aspartate aminotransferase/alanine aminotransferase levels at 21 days after injection.

Furthermore, BM-MSCs induced positive changes in serum bilirubin and albumin and downregulated expression of integrins (600- to 7000-fold), transforming growth factor, and procollagen-α1 compared with the control group.

Interestingly, both injection routes ameliorated inflammation and liver cirrhosis scores.

All mice in treatment groups had reduced inflammation scores and no cirrhosis.

In conclusion, transplantation of BM-MSCs via tail or portal veins ameliorates liver cirrhosis in mice.

Notably, there were no differences in treatment effects between tail and portal vein administrations.

In consideration of safety, we suggest transfusion of bone marrow-derived mesenchymal stem cells via a peripheral vein as a potential method for liver fibrosis treatment.

American Psychological Association (APA)

Truong, Nhung Hai& Nguyen, Nam Hai& Le, Trinh Van& Vu, Ngoc Bich& Huynh, Nghia& Nguyen, Thanh Van…[et al.]. 2015. Comparison of the Treatment Efficiency of Bone Marrow-Derived Mesenchymal Stem Cell Transplantation via Tail and Portal Veins in CCl4-Induced Mouse Liver Fibrosis. Stem Cells International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116801

Modern Language Association (MLA)

Truong, Nhung Hai…[et al.]. Comparison of the Treatment Efficiency of Bone Marrow-Derived Mesenchymal Stem Cell Transplantation via Tail and Portal Veins in CCl4-Induced Mouse Liver Fibrosis. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1116801

American Medical Association (AMA)

Truong, Nhung Hai& Nguyen, Nam Hai& Le, Trinh Van& Vu, Ngoc Bich& Huynh, Nghia& Nguyen, Thanh Van…[et al.]. Comparison of the Treatment Efficiency of Bone Marrow-Derived Mesenchymal Stem Cell Transplantation via Tail and Portal Veins in CCl4-Induced Mouse Liver Fibrosis. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116801

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1116801