Pathological Left Ventricular Hypertrophy and Stem Cells: Current Evidence and New Perspectives
Joint Authors
Marketou, Maria E.
Parthenakis, Fragiskos
Vardas, Panos E.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-20
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Left ventricular hypertrophy (LVH) is a strong predictor of adverse cardiovascular outcomes.
It is the result of complex mechanisms that include not only an increase in protein synthesis and cell size but also proliferating cardiac progenitor cells and the influx of bone marrow-derived cells developing into cardiomyocytes.
Stem and progenitor cells are known to contribute to the renewal of adult mammalian cardiomyocytes in case of myocardial injury or pressure and volume overload.
They are activated in LVH and play a regulatory role in myocardial repair.
They have high proliferative potential and secrete numerous cytokines, growth factors, and microRNAs that play important roles in cell differentiation, cardiac remodeling, and neovascularization.
They are mobilized in response to either mechanical or chemical stimuli, hormones, or pharmacologic agents.
Another important source of progenitor cells is the epicardial layer.
It appears that precursor cells migrate from the epicardium to the myocardium in order to interact with myocardial cells.
In addition, migratory cells participate in the formation of almost all cardiac structures in myocardial hypertrophy.
Although the pathophysiological mechanisms are still obscure and further studies are required, their properties may open the door to regenerative cell therapy for the prevention of adverse remodeling.
American Psychological Association (APA)
Marketou, Maria E.& Parthenakis, Fragiskos& Vardas, Panos E.. 2015. Pathological Left Ventricular Hypertrophy and Stem Cells: Current Evidence and New Perspectives. Stem Cells International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1116807
Modern Language Association (MLA)
Marketou, Maria E.…[et al.]. Pathological Left Ventricular Hypertrophy and Stem Cells: Current Evidence and New Perspectives. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1116807
American Medical Association (AMA)
Marketou, Maria E.& Parthenakis, Fragiskos& Vardas, Panos E.. Pathological Left Ventricular Hypertrophy and Stem Cells: Current Evidence and New Perspectives. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1116807
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116807