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Adipose-Derived Cells (Stromal Vascular Fraction) Transplanted for Orthopedical or Neurological Purposes: Are They Safe Enough?
Joint Authors
Dabrowska, Natalia L.
Maciagowska, Marzena
Zolocinska, Aleksandra
Mazur, Slawomir
Siennicka, Katarzyna
Pojda, Zygmunt
Stepien, Karolina
Zolocinska, Ewa
Slysz, Anna
Piusinska-Macoch, Renata
Zdanowicz, Urszula
Smigielski, Robert
Stępień, Adam
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-06
Country of Publication
Egypt
No. of Pages
5
Abstract EN
Although mesenchymal stem cells are used in numerous clinical trials, the safety of their application is still a matter of concern.
We have analysed the clinical results of the autologous adipose-derived stem cell treatment (stromal vascular fraction (SVF) containing adipose-derived stem cells, endothelial progenitors, and blood mononuclear cells) for orthopedic (cartilage, bone, tendon, or combined joint injuries) and neurologic (multiple sclerosis) diseases.
Methods of adipose tissue collection, cell isolation and purification, and resulting cell numbers, viability, and morphology were considered, and patient’s age, sex, disease type, and method of cell administration (cell numbers per single application, treatment numbers and frequency, and methods of cell implantation) were analysed and searched for the unwanted clinical effects.
Results of cellular therapy were compared retrospectively to those obtained with conventional medication without SVF application.
SVF transplantation was always the accessory treatment of patients receiving “standard routine” therapies of their diseases.
Clinical experiments were approved by the Bioethical Medical Committees supervising the centers where patients were hospitalised.
The conclusion of the study is that none of the treated patients developed any serious adverse event, and autologous mesenchymal stem (stromal) cell clinical application is a safe procedure resulting in some beneficial clinical effects (not analysed in this study).
American Psychological Association (APA)
Siennicka, Katarzyna& Zolocinska, Aleksandra& Stepien, Karolina& Dabrowska, Natalia L.& Maciagowska, Marzena& Zolocinska, Ewa…[et al.]. 2016. Adipose-Derived Cells (Stromal Vascular Fraction) Transplanted for Orthopedical or Neurological Purposes: Are They Safe Enough?. Stem Cells International،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1116818
Modern Language Association (MLA)
Siennicka, Katarzyna…[et al.]. Adipose-Derived Cells (Stromal Vascular Fraction) Transplanted for Orthopedical or Neurological Purposes: Are They Safe Enough?. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1116818
American Medical Association (AMA)
Siennicka, Katarzyna& Zolocinska, Aleksandra& Stepien, Karolina& Dabrowska, Natalia L.& Maciagowska, Marzena& Zolocinska, Ewa…[et al.]. Adipose-Derived Cells (Stromal Vascular Fraction) Transplanted for Orthopedical or Neurological Purposes: Are They Safe Enough?. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1116818
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116818