Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies
Joint Authors
Consalvi, Silvia
Sandoná, Martina
Saccone, Valentina
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-29
Country of Publication
Egypt
No. of Pages
11
Abstract EN
In the context of regenerative medicine, based on the potential of stem cells to restore diseased tissues, epigenetics is becoming a pivotal area of interest.
Therapeutic interventions that promote tissue and organ regeneration have as primary objective the selective control of gene expression in adult stem cells.
This requires a deep understanding of the epigenetic mechanisms controlling transcriptional programs in tissue progenitors.
This review attempts to elucidate the principle epigenetic regulations responsible of stem cells differentiation.
In particular we focus on the current understanding of the epigenetic networks that regulate differentiation of muscle progenitors by the concerted action of chromatin-modifying enzymes and noncoding RNAs.
The novel exciting role of exosome-bound microRNA in mediating epigenetic information transfer is also discussed.
Finally we show an overview of the epigenetic strategies and therapies that aim to potentiate muscle regeneration and counteract the progression of Duchenne Muscular Dystrophy (DMD).
American Psychological Association (APA)
Consalvi, Silvia& Sandoná, Martina& Saccone, Valentina. 2015. Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies. Stem Cells International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116868
Modern Language Association (MLA)
Consalvi, Silvia…[et al.]. Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1116868
American Medical Association (AMA)
Consalvi, Silvia& Sandoná, Martina& Saccone, Valentina. Epigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical Therapies. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116868
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116868